{"id":"W1955490869","doi":"10.1093/annonc/mdu340.9","title":"Clinical Activity of the Oral Selective Inhibitor of Nuclear Export (Sine) Selinexor (Kpt-330) in Patients with Head &amp; Neck Squamos Cell Carcinoma (Hn-Scc)","year":2014,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ozmosis Research (Canada)","funders":"","keywords":"Medicine; Head and neck; Sine; Nuclear export signal; Cancer research; Pharmacology; Surgery; Cell nucleus; Nucleus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003872466,0.0003060668,0.0007039017,0.0001904656,0.000160651,0.0003303369,0.0002241856,0.000344223,0.001073527],"category_scores_gemma":[0.0007394422,0.0001743688,0.000402277,0.0002599695,0.0002470333,0.0002864704,0.0001235737,0.0007387379,0.0002032614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002951698,"about_ca_system_score_gemma":0.0003793936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007061491,"about_ca_topic_score_gemma":0.002379264,"domain_scores_codex":[0.9998951,0.00003617327,0.000010759,0.00001962746,0.00001639491,0.0000218872],"domain_scores_gemma":[0.9996878,0.0001183193,0.00005480104,0.000014326,0.0000197094,0.0001051182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1543227,0.004113453,0.3883382,0.001133879,0.001384991,0.002053712,0.0004041795,0.002737749,0.07559163,0.0004512641,0.004435487,0.3650328],"study_design_scores_gemma":[0.0219778,0.1267108,0.8239291,0.0001405419,0.001798316,0.003113921,0.0003166749,0.002646065,0.009472834,0.0003235764,0.009501203,0.00006907504],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900676,0.006764119,0.0001413242,0.000296438,0.00004634382,0.00005866733,0.000388924,0.00002924335,0.002207321],"genre_scores_gemma":[0.9965822,0.001951893,0.0001191908,0.0001610908,0.0000447858,0.00002724566,0.0005160197,0.000003448517,0.0005940954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001073527,"threshold_uncertainty_score":0.003591359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02755906852539221,"score_gpt":0.3115242311421473,"score_spread":0.2839651626167551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}