{"id":"W1955653104","doi":"10.1007/s12104-015-9645-8","title":"15N, 13C and 1H backbone resonance assignments of an artificially engineered TEM-1/PSE-4 class A β-lactamase chimera and its deconvoluted mutant","year":2015,"lang":"en","type":"article","venue":"Biomolecular NMR Assignments","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Institut National de la Recherche Scientifique; Armand Frappier Museum; Université de Montréal; PROTEO","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada","keywords":"Chimera (genetics); Mutant; Chemistry; Stereochemistry; Resonance (particle physics); Computational biology; Crystallography; Biochemistry; Biology; Physics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004319371,0.0003982618,0.0004143339,0.00009789516,0.00008083856,0.00007705146,0.0003006543,0.0003123357,0.00001510663],"category_scores_gemma":[0.0001900145,0.0004001665,0.00007085539,0.0001690817,0.0001906652,0.00003084097,0.0002993931,0.0001104436,0.000008412898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005497192,"about_ca_system_score_gemma":0.0001681147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001800243,"about_ca_topic_score_gemma":0.00001325836,"domain_scores_codex":[0.9974812,0.0002083035,0.0005597515,0.0007992407,0.0004678665,0.0004836893],"domain_scores_gemma":[0.9985099,0.00001312263,0.0002767395,0.0005997092,0.0001583757,0.0004421001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000403773,0.0002466252,0.003257175,0.0000438405,0.0001373497,0.00005853749,0.00007726686,0.000008096924,0.9938464,0.00008047171,0.0002481935,0.001592321],"study_design_scores_gemma":[0.003019569,0.0009850888,0.02171558,0.000107804,0.00009085544,0.00006372079,0.0001724027,0.001517715,0.9662803,0.0001292808,0.005277389,0.0006402323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935675,0.002301484,0.002946481,0.00009052513,0.0001719514,0.0005116572,0.0001155159,0.00002458662,0.000270317],"genre_scores_gemma":[0.9965682,0.0001559041,0.002505591,0.0001590571,0.00008920205,0.00001644591,0.0001773193,0.00006847767,0.0002598117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02756599,"threshold_uncertainty_score":0.999845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01608018876664885,"score_gpt":0.2576234333539388,"score_spread":0.24154324458729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}