{"id":"W1955741196","doi":"10.1080/09168451.2015.1072461","title":"Long time-course monitoring of ZFP809-mediated gene silencing in transgene expression driven by promoters containing MLV-derived PBS","year":2015,"lang":"en","type":"article","venue":"Bioscience Biotechnology and Biochemistry","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Health, British Columbia; National Center for Child Health and Development","keywords":"Gene silencing; Biology; Transgene; Gene; Promoter; RNA interference; Molecular biology; Gene expression; Reporter gene; Embryonic stem cell; Cell biology; Genetics; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005017295,0.0002317593,0.0002488294,0.0001036762,0.00008620826,0.00001753302,0.0004849721,0.0006739055,0.000005029706],"category_scores_gemma":[0.0001783164,0.0002214793,0.00004662999,0.0003470946,0.0007781102,0.00001306956,0.0001917011,0.000246463,0.000002464614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004578473,"about_ca_system_score_gemma":0.0002581679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001430461,"about_ca_topic_score_gemma":0.000005200679,"domain_scores_codex":[0.9982289,0.00005841946,0.0003272078,0.0006644253,0.0002477353,0.0004732981],"domain_scores_gemma":[0.9991696,0.00001659664,0.000143444,0.0004128665,0.00008362284,0.0001737993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004368571,0.00009734133,0.0125595,0.00002256345,0.0000144219,0.000009360315,0.00008967896,0.000009273653,0.9852136,1.411158e-7,0.0000378167,0.001509477],"study_design_scores_gemma":[0.0009743417,0.001192097,0.0007992124,0.00007872721,0.000006701083,0.00001882203,0.0004456576,0.0001289978,0.9960852,0.000004467056,0.000023021,0.0002428138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963075,0.002841637,0.0001879963,0.0003190739,0.00006099616,0.0001936679,0.00003394981,0.00003858657,0.00001659849],"genre_scores_gemma":[0.9985629,0.0004569945,0.0007521695,0.00002711012,0.00004928507,0.00002022395,0.00005930656,0.00001858208,0.00005347518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01176029,"threshold_uncertainty_score":0.9031665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01463193993403542,"score_gpt":0.2741810643197309,"score_spread":0.2595491243856954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}