{"id":"W1955853807","doi":"10.1002/bmc.2741","title":"LC‐MS/MS method for simultaneous analysis of uracil, 5,6‐dihydrouracil, 5‐fluorouracil and 5‐fluoro‐5,6‐dihydrouracil in human plasma for therapeutic drug monitoring and toxicity prediction in cancer patients","year":2012,"lang":"en","type":"article","venue":"Biomedical Chromatography","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Chemistry; Formic acid; Chromatography; Therapeutic drug monitoring; Uracil; Ammonium acetate; Dihydropyrimidine dehydrogenase; Selected reaction monitoring; Analyte; High-performance liquid chromatography; Fluorouracil; Quantitative analysis (chemistry); Therapeutic index; Pharmacokinetics; Mass spectrometry; Tandem mass spectrometry; Drug; Pharmacology; Cancer; Biochemistry; Thymidylate synthase; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005702545,0.0003507249,0.001030612,0.001028198,0.0001685471,0.00002089655,0.00008436235,0.0002085759,0.0000250793],"category_scores_gemma":[0.0001430185,0.0002836385,0.0002762021,0.00131518,0.0002410761,0.0001786104,0.00006479686,0.0001704842,1.846099e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002136215,"about_ca_system_score_gemma":0.00004274317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001261967,"about_ca_topic_score_gemma":0.0005414197,"domain_scores_codex":[0.9976352,0.00008797656,0.000732997,0.0005013348,0.0004574751,0.0005849874],"domain_scores_gemma":[0.9984128,0.000731405,0.0002323016,0.0001887124,0.0001443135,0.0002904615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007116343,0.001448553,0.9506404,0.0005090942,0.001772835,0.000004290098,0.002999207,0.00003000955,0.006496493,0.00001751359,0.00008130045,0.03528861],"study_design_scores_gemma":[0.008332722,0.001835501,0.9599183,0.0003547943,0.00271709,0.000007591784,0.0006187669,0.01870796,0.005510918,0.00009571674,0.001488503,0.0004121247],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929613,0.004295382,0.0004064182,0.0001909107,0.0001798922,0.001409364,0.000455043,0.00004461061,0.00005703827],"genre_scores_gemma":[0.9966323,0.0005869319,0.001742368,0.00003842317,0.0001526227,0.000654752,0.0001313948,0.00003059118,0.00003055421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03487649,"threshold_uncertainty_score":0.9999616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02208178883577461,"score_gpt":0.3303692480902947,"score_spread":0.3082874592545201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}