{"id":"W1955942895","doi":"10.1124/jpet.103.064691","title":"Preferential Inhibition of T Helper 1, but Not T Helper 2, Cytokines in Vitro by L-826,141 [4-{2-(3,4-Bisdifluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a Potent and Selective Phosphodiesterase 4 Inhibitor","year":2004,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Rolipram; Cytokine; Tumor necrosis factor alpha; Peripheral blood mononuclear cell; Ovalbumin; T cell; Chemistry; Molecular biology; Biology; In vitro; Phosphodiesterase; Immunology; Immune system; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002994787,0.0005666302,0.0004376174,0.0002076105,0.0001254151,0.0003127932,0.000258912,0.0002846395,0.001873429],"category_scores_gemma":[0.0001805299,0.0002242974,0.0002367095,0.0001594533,0.000197944,0.0001804602,0.000139685,0.0008546928,0.0007325201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001979196,"about_ca_system_score_gemma":0.0003471027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003483715,"about_ca_topic_score_gemma":0.0008074878,"domain_scores_codex":[0.999739,0.00005136065,0.00002200361,0.00003108515,0.00003484926,0.0001217496],"domain_scores_gemma":[0.9998361,0.00005858023,0.00002677526,0.00001950425,0.00001168574,0.00004729557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008974507,0.0001125648,0.0001187363,0.00005480547,0.000004504566,0.00006843527,0.0000113731,0.00008213258,0.9970939,0.00006602962,0.00009459904,0.001395494],"study_design_scores_gemma":[0.0001565883,0.001530271,0.001757679,0.000005906662,0.00001719822,0.0002044446,0.00001341638,0.0004499277,0.9946871,0.00002500243,0.0011488,0.000003628188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874738,0.005050571,0.001844866,0.0001577593,0.0001603854,0.00006327285,0.0005615067,0.0001382116,0.004549747],"genre_scores_gemma":[0.9927561,0.00195996,0.001366248,0.00009184153,0.00009533911,0.0000560799,0.0007089705,0.00002396318,0.002941454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001873429,"threshold_uncertainty_score":0.00626725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01219050924459143,"score_gpt":0.2809521604573458,"score_spread":0.2687616512127544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}