{"id":"W1955942895","doi":"10.1124/jpet.103.064691","title":"Preferential Inhibition of T Helper 1, but Not T Helper 2, Cytokines in Vitro by L-826,141 [4-{2-(3,4-Bisdifluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a Potent and Selective Phosphodiesterase 4 Inhibitor","year":2004,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Rolipram; Cytokine; Tumor necrosis factor alpha; Peripheral blood mononuclear cell; Ovalbumin; T cell; Chemistry; Molecular biology; Biology; In vitro; Phosphodiesterase; Immunology; Immune system; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003553662,0.0003422508,0.0004799746,0.0001833507,0.0001193297,0.00002952411,0.0001036815,0.0002938803,0.00002353234],"category_scores_gemma":[0.000014808,0.0002983685,0.0001432459,0.0001452465,0.0003373506,0.0000597273,0.0001143267,0.0003239662,9.161398e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000117427,"about_ca_system_score_gemma":0.000127525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003250779,"about_ca_topic_score_gemma":0.000004073952,"domain_scores_codex":[0.9981208,0.0002246206,0.0007295599,0.0003613422,0.0002490485,0.0003146197],"domain_scores_gemma":[0.9990569,0.00003990141,0.0004594536,0.0001093136,0.0001955176,0.0001389249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005596702,0.0007866484,0.0002077907,0.00003626593,0.0002951761,0.00001361574,0.0008283547,0.0001459507,0.9907555,0.000009544185,0.0002659489,0.001058518],"study_design_scores_gemma":[0.007241081,0.001492547,0.0005983211,0.00004029763,0.0001366264,0.0001983637,0.0006249664,0.00007710076,0.9878594,0.00008473011,0.001354983,0.0002915792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898172,0.008039816,0.0007113792,0.0004269276,0.0005938287,0.0003179671,0.0000575974,0.000008354723,0.0000269221],"genre_scores_gemma":[0.9955847,0.00143655,0.001139464,0.001381994,0.0002710023,0.00002196786,0.00004634065,0.00003552854,0.00008245598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006603266,"threshold_uncertainty_score":0.9999468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01219050924459143,"score_gpt":0.2809521604573458,"score_spread":0.2687616512127544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}