{"id":"W1955966143","doi":"10.1002/ijc.28432","title":"Loss of PPARγ expression in mammary secretory epithelial cells creates a pro‐breast tumorigenic environment","year":2013,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Cure Brain Cancer Foundation; Ontario Ministry of Research and Innovation; Queen's University; Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"DMBA; Endocrinology; Internal medicine; Peroxisome proliferator-activated receptor; Mammary gland; Mammary tumor; PTEN; Breast cancer; Carcinogenesis; Cancer research; Involution (esoterism); Biology; Medicine; Apoptosis; Cancer; Receptor; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002179356,0.000322093,0.0003250111,0.0004051275,0.0002117951,0.0005062618,0.000245405,0.0003848767,0.002439342],"category_scores_gemma":[0.0001186486,0.0003520603,0.0004132387,0.0002977776,0.0003349759,0.0002318645,0.0004340854,0.001068093,0.0008018631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002994581,"about_ca_system_score_gemma":0.0003673933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00069459,"about_ca_topic_score_gemma":0.001376611,"domain_scores_codex":[0.9996877,0.00003863449,0.00003388703,0.00006743189,0.0001077334,0.00006464928],"domain_scores_gemma":[0.9997968,0.00001930494,0.00006588839,0.00003641504,0.00002078594,0.00006087999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001125523,0.00002573654,0.0003943371,0.00002253937,0.000004736824,0.00004621899,0.00001480541,0.00002703638,0.9984712,0.00008326831,0.00003430137,0.0007631775],"study_design_scores_gemma":[0.00002669269,0.0004892438,0.008676831,0.0000160378,0.00003104715,0.0006244727,0.0001439936,0.0004200878,0.983325,0.00009502331,0.006143838,0.000007692467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911134,0.001314704,0.004047552,0.0002943303,0.00006561812,0.0000354118,0.001183652,0.0001513441,0.001794117],"genre_scores_gemma":[0.9852663,0.001853778,0.002410127,0.0001406443,0.00001320308,0.00006001298,0.001558518,0.00004861084,0.008648956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002439342,"threshold_uncertainty_score":0.008160412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005252569540904335,"score_gpt":0.2414009897205945,"score_spread":0.2361484201796901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}