{"id":"W1956090840","doi":"10.4049/jimmunol.181.3.2165","title":"Activated Protein C Up-Regulates IL-10 and Inhibits Tissue Factor in Blood Monocytes","year":2008,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Hamilton Health Sciences; Juravinski Hospital","funders":"McMaster University; Oklahoma Medical Research Foundation","keywords":"Recombinant DNA; Protein C; Endothelial protein C receptor; Molecular biology; Monocyte; Biology; Tissue factor; Serine protease; Cytokine; Chemistry; Protease; Immunology; Biochemistry; Thrombin; Internal medicine; Medicine; Coagulation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001817043,0.0004216352,0.0002757943,0.000260304,0.0001047697,0.0002662201,0.0001075441,0.0002174791,0.0008942338],"category_scores_gemma":[0.0002414256,0.00007710683,0.0002559134,0.0001431053,0.000195333,0.00007722818,0.0001255175,0.0004381895,0.000371827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001899453,"about_ca_system_score_gemma":0.0002692899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004874803,"about_ca_topic_score_gemma":0.0004201345,"domain_scores_codex":[0.9998149,0.00005484733,0.00001692362,0.00001946493,0.00003410628,0.00005980378],"domain_scores_gemma":[0.9998367,0.00003875229,0.0000367264,0.00001812793,0.00002484725,0.00004491727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000820092,0.0001192286,0.0003884871,0.00005481857,0.000007923828,0.000128675,0.00001750941,0.00006232408,0.9946035,0.00003224505,0.00008998955,0.003675185],"study_design_scores_gemma":[0.0002457612,0.002624585,0.02381395,0.00002217191,0.00006680725,0.0009847665,0.00004721719,0.002010088,0.9651785,0.00009855485,0.004894758,0.000012773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923297,0.004071075,0.002075118,0.0001368168,0.00005455119,0.00005125896,0.0001283195,0.00006623319,0.001086965],"genre_scores_gemma":[0.9945691,0.001424781,0.002440843,0.0001229672,0.00004944605,0.00006103554,0.0002525049,0.00001236858,0.001067046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008942338,"threshold_uncertainty_score":0.002991557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02868332831104891,"score_gpt":0.2660380092897573,"score_spread":0.2373546809787084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}