{"id":"W1956266937","doi":"10.1038/ncomms8871","title":"Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Cancerfonden; European Synchrotron Radiation Facility; Wenner-Gren Stiftelserna","keywords":"Nucleotide; Biochemistry; DNA; Enzyme; Oxidative phosphorylation; Chemistry; HEK 293 cells; Substrate (aquarium); Cell culture; Biology; Cell biology; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":{"n_in":0,"stratum":"fund_new","weight":1678.9,"opus":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"Structural and cellular study separating the functions of MTH1 and MTH2/NUDT15; the object is enzyme biology."},"gpt":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"The study investigates molecular functions in cancer biology rather than research itself."},"grok":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"Structural and cellular biochemistry of MTH1/MTH2 enzymes; cancer biology domain research."}}}