{"id":"W1956964428","doi":"10.4049/jimmunol.170.6.2877","title":"T Cell Activation In Vivo Targets Diacylglycerol Kinase α to the Membrane: A Novel Mechanism for Ras Attenuation","year":2003,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Centro Nacional de Biotecnología","keywords":"Diacylglycerol kinase; Biology; Cell biology; Second messenger system; In vivo; Phosphatidic acid; Molecular biology; Protein kinase C; Signal transduction; Biochemistry; Phospholipid; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009520115,0.0004487483,0.0002241431,0.0001498416,0.0001731202,0.0005226785,0.000248316,0.0002628869,0.000923533],"category_scores_gemma":[0.0001200391,0.0001410379,0.0002883303,0.00009670713,0.0003342553,0.0003878244,0.0002072531,0.0007684793,0.0005160829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004171093,"about_ca_system_score_gemma":0.0001254006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001805193,"about_ca_topic_score_gemma":0.0001844473,"domain_scores_codex":[0.9998608,0.00002042769,0.000009255876,0.00003638362,0.00003767248,0.00003543247],"domain_scores_gemma":[0.9998899,0.00001661641,0.00003152287,0.00002405069,0.0000176253,0.00002034264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000356186,0.00000398457,0.00005494296,0.000007653144,0.000001047093,0.00002352914,0.000006281632,0.00001451306,0.9993705,0.00009658878,0.000004619719,0.0003806991],"study_design_scores_gemma":[0.000007308577,0.0000953777,0.001387107,0.00000243979,0.000008842519,0.0002413761,0.00001409891,0.0005224096,0.9963977,0.0000889827,0.001232399,0.000001984324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808043,0.002287277,0.01487177,0.0002048519,0.00005060431,0.00002423182,0.0001079529,0.0002244719,0.001424545],"genre_scores_gemma":[0.9947312,0.0009632303,0.002345165,0.00003562875,0.00001413653,0.00001475268,0.0001039213,0.00002338907,0.001768648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000923533,"threshold_uncertainty_score":0.003089547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01155918923415494,"score_gpt":0.237202790345905,"score_spread":0.2256436011117501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}