{"id":"W1958864771","doi":"10.1186/s12967-015-0616-8","title":"Deletion of angiotensin-converting enzyme 2 exacerbates renal inflammation and injury in apolipoprotein E-deficient mice through modulation of the nephrin and TNF-alpha-TNFRSF1A signaling","year":2015,"lang":"en","type":"article","venue":"Journal of Translational Medicine","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Key Research and Development Program of China; Science and Technology Commission of Shanghai Municipality; Major Research Plan; National Natural Science Foundation of China","keywords":"Nephrin; Endocrinology; Internal medicine; Angiotensin-converting enzyme 2; Apolipoprotein E; Proinflammatory cytokine; Angiotensin II; Kidney; Medicine; Inflammation; Tumor necrosis factor alpha; Blood urea nitrogen; Receptor; Proteinuria; Podocyte","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003615768,0.0009516943,0.0005812597,0.0006556389,0.0002370078,0.0005103885,0.0003723282,0.0006341182,0.001524021],"category_scores_gemma":[0.0001592772,0.0004507981,0.0005586516,0.000221109,0.0004776938,0.000433216,0.0002974966,0.001213067,0.0003863256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000371174,"about_ca_system_score_gemma":0.0003516201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003864801,"about_ca_topic_score_gemma":0.001009198,"domain_scores_codex":[0.9996675,0.00004731227,0.0000478082,0.00007398911,0.00007960668,0.00008383152],"domain_scores_gemma":[0.9994887,0.00003028749,0.0002185152,0.00002894018,0.00002356705,0.0002098724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000801105,0.0002409587,0.0006222997,0.00005331837,0.00001752478,0.0002115984,0.00002798612,0.00005490857,0.9971336,0.00007229974,0.00004299863,0.000721563],"study_design_scores_gemma":[0.0004305963,0.003588279,0.03273505,0.0000566371,0.0001636441,0.002026647,0.0002058005,0.001742124,0.9564229,0.0002345737,0.002364547,0.00002922387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967874,0.000784874,0.001301612,0.0001304013,0.00003221585,0.00003699276,0.0002715607,0.00009560336,0.0005592851],"genre_scores_gemma":[0.9906844,0.001134937,0.003663082,0.0001653896,0.00003460343,0.0001221226,0.0004904118,0.00005550074,0.003649548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001524021,"threshold_uncertainty_score":0.005098403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03268934886135994,"score_gpt":0.2810841791925079,"score_spread":0.248394830331148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}