{"id":"W1959161743","doi":"10.1093/infdis/jiv448","title":"λ Light Chain Bias Associated With Enhanced Binding and Function of Anti-HIV Env Glycoprotein Antibodies","year":2015,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Bill and Melinda Gates Foundation; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Immunoglobulin light chain; Virology; Antibody; Neutralization; Somatic hypermutation; Context (archaeology); Biology; Immunology; Humoral immunity; Toxoid; Immune system; Tetanus; Vaccination; B cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002903405,0.0001507803,0.000138673,0.0003074973,0.0001376456,0.0003001458,0.0001038127,0.0002176484,0.001464999],"category_scores_gemma":[0.0004185857,0.00009981337,0.0001004753,0.0001169648,0.0001829706,0.0001724715,0.0001716075,0.0002439698,0.0001704334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001658995,"about_ca_system_score_gemma":0.00009908865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005407646,"about_ca_topic_score_gemma":0.0004721142,"domain_scores_codex":[0.9997858,0.00005304598,0.00001163533,0.00004101789,0.00004086207,0.00006756622],"domain_scores_gemma":[0.9997235,0.00007739081,0.00008485084,0.00002560352,0.00004875934,0.00003985398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006416225,0.00009083452,0.1900674,0.00004479591,0.00002781343,0.0002674765,0.0002425976,0.00007372951,0.800589,0.0001730885,0.0000744593,0.007707177],"study_design_scores_gemma":[0.00002836454,0.001156695,0.8869885,0.00001916923,0.00005011087,0.0035044,0.0003188399,0.000728595,0.1055494,0.0002717134,0.001372963,0.000011255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992661,0.0001576006,0.0001609887,0.000008319757,0.000001793389,0.000002865828,0.00001451448,0.000003619555,0.0003842954],"genre_scores_gemma":[0.9995918,0.00005324372,0.00009542628,0.00002080612,0.00000342566,0.000002080514,0.00001632965,0.000002105364,0.0002147677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001464999,"threshold_uncertainty_score":0.004900873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01634746272689654,"score_gpt":0.2445919094856879,"score_spread":0.2282444467587914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}