{"id":"W1959193829","doi":"10.1002/eji.201343774","title":"2<scp>D TCR</scp>–p<scp>MHC</scp>–<scp>CD</scp>8 kinetics determines <scp>T</scp>‐cell responses in a self‐antigen‐specific <scp>TCR</scp> system","year":2013,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institute of General Medical Sciences; U.S. Public Health Service; York University; National Institute of Allergy and Infectious Diseases; Georgia Institute of Technology","keywords":"T-cell receptor; Major histocompatibility complex; T cell; Biology; CD8; Receptor; Antigen; Antigen-presenting cell; Cell biology; Peptide; Immune system; Biochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001062081,0.0001922379,0.000130781,0.0001317027,0.00008323164,0.0002654253,0.0001180302,0.0001751574,0.001824557],"category_scores_gemma":[0.0002206177,0.0001594815,0.00008703597,0.000145045,0.0001454971,0.0001769063,0.00007565913,0.0002815771,0.0004379642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001934368,"about_ca_system_score_gemma":0.0001058228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000556893,"about_ca_topic_score_gemma":0.0005857222,"domain_scores_codex":[0.9999008,0.00001354085,0.000005657928,0.00002832425,0.0000341401,0.00001757531],"domain_scores_gemma":[0.9998842,0.0000517179,0.00002636111,0.00001201076,0.00001334311,0.00001237313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006696976,0.00001645076,0.0005475121,0.00001308356,0.000002810228,0.00001718675,0.000005800292,0.0008836988,0.9974186,0.00009516762,0.00003830866,0.0008942707],"study_design_scores_gemma":[0.0000119918,0.0001108317,0.006388281,0.000001939199,0.00000864739,0.0002497013,0.00001933931,0.02983462,0.9623538,0.0001517882,0.0008586317,0.00001045166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909456,0.00009406397,0.007498847,0.00002311922,0.000003889792,0.000008701117,0.000183611,0.00004611085,0.001196103],"genre_scores_gemma":[0.9944379,0.0001290088,0.003947174,0.0000175525,0.000002517503,0.00001709217,0.0004102107,0.00002135733,0.00101714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001824557,"threshold_uncertainty_score":0.006103754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01329356485278557,"score_gpt":0.2093302842891916,"score_spread":0.196036719436406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}