{"id":"W1959193829","doi":"10.1002/eji.201343774","title":"2<scp>D TCR</scp>–p<scp>MHC</scp>–<scp>CD</scp>8 kinetics determines <scp>T</scp>‐cell responses in a self‐antigen‐specific <scp>TCR</scp> system","year":2013,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institute of General Medical Sciences; U.S. Public Health Service; York University; National Institute of Allergy and Infectious Diseases; Georgia Institute of Technology","keywords":"T-cell receptor; Major histocompatibility complex; T cell; Biology; CD8; Receptor; Antigen; Antigen-presenting cell; Cell biology; Peptide; Immune system; Biochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.003568167,0.002033708,0.002848135,0.003064958,0.001044611,0.0005842465,0.003020004,0.001448642,0.0002518403],"category_scores_gemma":[0.008430287,0.001909962,0.00133804,0.001544531,0.001142369,0.001456252,0.001046426,0.004935266,0.01420263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000749453,"about_ca_system_score_gemma":0.0004851321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001100633,"about_ca_topic_score_gemma":0.00002580926,"domain_scores_codex":[0.9813014,0.008079489,0.004982757,0.001761028,0.0005515873,0.003323695],"domain_scores_gemma":[0.981096,0.01001582,0.004450531,0.00212008,0.001900392,0.0004171855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001014265,0.001339516,0.003049241,0.0001936867,0.001407322,0.001228946,0.006978081,0.000103714,0.6999035,0.0001689263,0.2840661,0.001459498],"study_design_scores_gemma":[0.006248655,0.003622881,0.04652765,0.0006621048,0.0002987825,0.00750593,0.02644669,0.00004708751,0.1495815,0.00003384771,0.7588426,0.000182214],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8990589,0.03939519,0.000607938,0.0001295086,0.01758461,0.001195555,0.00005719177,0.0005517393,0.04141935],"genre_scores_gemma":[0.869571,0.01103525,0.0007868468,0.0007924954,0.001180294,0.00007733153,0.0002375748,0.0005774567,0.1157417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.550322,"threshold_uncertainty_score":0.9999221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01329356485278557,"score_gpt":0.2093302842891916,"score_spread":0.196036719436406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}