{"id":"W1959266552","doi":"10.1186/s12918-015-0185-8","title":"Complex regulation of Hsf1-Skn7 activities by the catalytic subunits of PKA in Saccharomyces cerevisiae: experimental and computational evidences","year":2015,"lang":"en","type":"article","venue":"BMC Systems Biology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of British Columbia Hospital","funders":"Consejo Nacional de Ciencia y Tecnología; Fundación Marcos Moshinsky","keywords":"Chemistry; Saccharomyces cerevisiae; Repressor; HSF1; Yeast; Protein kinase A; Biochemistry; Transcription factor; Biophysics; Gene; Kinase; Biology; Heat shock protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003378912,0.00008950282,0.0001901312,0.00004818731,0.00002761886,0.000008264735,0.00009103792,0.00008719833,0.00000391774],"category_scores_gemma":[0.00005181973,0.00006741221,0.00002713077,0.00007123758,0.0002117816,0.000007097952,0.00005203116,0.00002709493,4.03275e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001280968,"about_ca_system_score_gemma":0.00007172184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002397668,"about_ca_topic_score_gemma":0.00002806188,"domain_scores_codex":[0.9991278,0.0002400759,0.000290933,0.0001619837,0.00008658451,0.00009263254],"domain_scores_gemma":[0.9995149,0.00006282403,0.0002114113,0.0001184876,0.00006183187,0.00003051023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001064023,0.00004239731,0.03676152,0.0001073502,0.00002734552,1.723552e-7,0.0002742905,0.001428209,0.9589921,0.001641327,0.0003794914,0.0002393817],"study_design_scores_gemma":[0.002776661,0.0009781508,0.03565772,0.0003162794,0.00003203033,0.0001287562,0.006193995,0.01809201,0.9310015,0.000671617,0.003686201,0.0004650184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878258,0.01042555,0.001270768,0.00003364967,0.00005855073,0.0002585715,0.00003488983,0.000003564919,0.00008872968],"genre_scores_gemma":[0.9994953,0.00001271775,0.0001784988,0.00001103939,0.00004626181,0.00002049261,0.0001903797,0.000005367944,0.00003992136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02799055,"threshold_uncertainty_score":0.274899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05198424806351795,"score_gpt":0.3009470442793198,"score_spread":0.2489627962158018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}