{"id":"W1959418382","doi":"10.1111/jphp.12165","title":"Osteoarthritis of the hand II: chemistry, pharmacokinetics and pharmacodynamics of naproxen, and clinical outcome studies","year":2013,"lang":"en","type":"review","venue":"Journal of Pharmacy and Pharmacology","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Hamilton Health Sciences","funders":"","keywords":"Naproxen; Osteoarthritis; Medicine; Drug class; Context (archaeology); Adverse effect; Placebo; Clinical trial; Pharmacology; Pharmacodynamics; Drug; Intensive care medicine; Pharmacokinetics; Internal medicine; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003255136,0.0005185595,0.001970446,0.001346244,0.0001753283,0.001324715,0.0005076029,0.0005378882,0.002193909],"category_scores_gemma":[0.006313234,0.0001589712,0.001238292,0.001900705,0.0004384193,0.000869899,0.0003665314,0.0008203775,0.0004556936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000740698,"about_ca_system_score_gemma":0.001204207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001109771,"about_ca_topic_score_gemma":0.001731406,"domain_scores_codex":[0.9981582,0.0005062465,0.0003915542,0.0002118456,0.0006620474,0.0000700411],"domain_scores_gemma":[0.995196,0.00252995,0.001475427,0.00008712298,0.0006037812,0.000107662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004664007,0.000510023,0.02731532,0.07097704,0.003252866,0.0004832519,0.0002003743,0.000659141,0.004440248,0.001610465,0.00906463,0.8768227],"study_design_scores_gemma":[0.002062176,0.03003794,0.4448577,0.1136157,0.02478345,0.02317754,0.001620973,0.002102568,0.009309847,0.00696914,0.3410487,0.0004142874],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002660044,0.9960663,0.0001303518,0.0003363583,0.00006667307,0.00002285363,0.00008088913,0.000003201275,0.0006333528],"genre_scores_gemma":[0.04623882,0.9502185,0.0006706525,0.000721899,0.001086316,0.00007382389,0.00030847,0.000006418651,0.0006749736],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003255136,"threshold_uncertainty_score":0.01721495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09306420010660217,"score_gpt":0.4635646170734996,"score_spread":0.3705004169668974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}