{"id":"W1959861774","doi":"10.4049/jimmunol.172.10.6251","title":"<i>Mycobacterium tuberculosis</i> -Induced CXCR4 and Chemokine Expression Leads to Preferential X4 HIV-1 Replication in Human Macrophages","year":2004,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; York University; National Institutes of Health; Uehara Memorial Foundation; Center for AIDS Research, University of Washington; National Heart, Lung, and Blood Institute; American Lung Association","keywords":"Bronchoalveolar lavage; Chemokine; CXCR4; Mycobacterium tuberculosis; Virology; Biology; Tuberculosis; CXCL16; CCL5; Coinfection; Immunology; Viral replication; Retrovirus; CXCL10; CX3CL1; Chemokine receptor; Virus; Medicine; Inflammation; Lung; T cell; Pathology; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004816005,0.0001496106,0.0003000013,0.0002020761,0.0001634861,0.00001291627,0.0002997507,0.0001692357,0.0001307436],"category_scores_gemma":[0.00008700372,0.00009496637,0.00005409825,0.0001340827,0.0001391851,0.00009934093,0.0001615833,0.00050097,0.0001505012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001130663,"about_ca_system_score_gemma":0.00006075449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009403202,"about_ca_topic_score_gemma":0.00003374638,"domain_scores_codex":[0.9986974,0.0003235059,0.0004216217,0.0001759323,0.00005158143,0.0003299567],"domain_scores_gemma":[0.9992089,0.00007743604,0.0001951722,0.0003900374,0.0000958004,0.00003261611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007793123,0.0002175899,0.001330868,0.000006871308,0.0001175233,0.0000125968,0.0007708247,0.000008580922,0.9938949,0.00005155669,0.0003415672,0.002467842],"study_design_scores_gemma":[0.003366613,0.001120478,0.08113648,0.00007263423,0.00003902232,0.0006505228,0.0001534181,4.890907e-8,0.9119655,0.0001561154,0.001251761,0.00008736795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945553,0.002390404,0.00006107541,0.002402481,0.0001876537,0.0002363688,0.00001191013,0.00001144315,0.0001433808],"genre_scores_gemma":[0.9990023,0.0005332018,0.00006141546,0.00008050463,0.00004190933,0.00001323238,0.0000316192,0.00001243259,0.0002233225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08192933,"threshold_uncertainty_score":0.3872616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01480404582915399,"score_gpt":0.276089402356937,"score_spread":0.261285356527783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}