{"id":"W1959861774","doi":"10.4049/jimmunol.172.10.6251","title":"<i>Mycobacterium tuberculosis</i> -Induced CXCR4 and Chemokine Expression Leads to Preferential X4 HIV-1 Replication in Human Macrophages","year":2004,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; York University; National Institutes of Health; Uehara Memorial Foundation; Center for AIDS Research, University of Washington; National Heart, Lung, and Blood Institute; American Lung Association","keywords":"Bronchoalveolar lavage; Chemokine; CXCR4; Mycobacterium tuberculosis; Virology; Biology; Tuberculosis; CXCL16; CCL5; Coinfection; Immunology; Viral replication; Retrovirus; CXCL10; CX3CL1; Chemokine receptor; Virus; Medicine; Inflammation; Lung; T cell; Pathology; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001498763,0.0001743808,0.0001566229,0.0001220245,0.0001735117,0.0002760618,0.00008579253,0.0001729549,0.001473389],"category_scores_gemma":[0.0001031056,0.0001152201,0.0001686415,0.00008737501,0.000137605,0.00007676802,0.0001478051,0.0002840179,0.0005904664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002035368,"about_ca_system_score_gemma":0.0001263511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004331407,"about_ca_topic_score_gemma":0.0004086048,"domain_scores_codex":[0.9998574,0.00003044423,0.00001514297,0.00002242215,0.00002173793,0.00005286156],"domain_scores_gemma":[0.999948,0.00001011999,0.00001264476,0.00000877694,0.000008183372,0.00001219861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001734268,0.0000195228,0.0005833665,0.00002505781,0.000002387789,0.00005455603,0.00001292759,0.00001758758,0.9981488,0.00003524287,0.00006081349,0.0008663526],"study_design_scores_gemma":[0.00003872785,0.0008205778,0.0223657,0.00001645884,0.00002072314,0.0009394948,0.0000722219,0.000499593,0.9715537,0.00006340785,0.003604799,0.000004591283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968531,0.001257063,0.0005191927,0.00009848634,0.00001857378,0.00001375365,0.0002095915,0.00003949559,0.0009907838],"genre_scores_gemma":[0.9960382,0.0006195264,0.0008214043,0.00009465365,0.00002082412,0.00003402716,0.000571349,0.00001075322,0.001789206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001473389,"threshold_uncertainty_score":0.004929006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01480404582915399,"score_gpt":0.276089402356937,"score_spread":0.261285356527783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}