{"id":"W1960117778","doi":"10.1039/c5mb00278h","title":"RNAi therapeutics for brain cancer: current advancements in RNAi delivery strategies","year":2015,"lang":"en","type":"review","venue":"Molecular BioSystems","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Irish Research Council; Fonds de Recherche du Québec - Santé; Irish Cancer Society","keywords":"RNA interference; Gene silencing; Angiogenesis; Blood–brain barrier; Biology; Metastasis; Cancer; Cancer research; Central nervous system; Brain tumor; Medicine; Neuroscience; Gene; Pathology; RNA; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004283632,0.0006866716,0.001230538,0.0002073046,0.00005372547,0.0001181283,0.0006933752,0.0005401919,0.000006674117],"category_scores_gemma":[0.00002308969,0.0006106179,0.0005744541,0.0002266644,0.00005956868,0.00001103072,0.0001819237,0.0002620356,0.00002156841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001743452,"about_ca_system_score_gemma":0.001053261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006712099,"about_ca_topic_score_gemma":0.0001319518,"domain_scores_codex":[0.9970878,0.0002800208,0.000861705,0.0008878906,0.0002967903,0.0005857961],"domain_scores_gemma":[0.998416,0.00002144815,0.0004485542,0.0007182197,0.0002670616,0.0001287301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007335661,0.0001676796,0.00001938609,0.01094032,0.0006702573,0.00002534706,0.00005851181,0.00005189496,0.01024513,0.00007994944,0.005965898,0.9717023],"study_design_scores_gemma":[0.0005445894,0.0002755835,6.480584e-7,0.004272481,0.0002566444,0.00001101249,0.00009828058,0.00002371375,0.001368444,0.00003635121,0.9924386,0.0006736372],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001740164,0.9929447,0.001238578,0.00003032625,0.001562776,0.001794552,0.0005597513,0.00001851971,0.0001106505],"genre_scores_gemma":[0.00191288,0.9946054,0.00007262371,0.0001524863,0.0004464473,0.0009741081,0.001423222,0.0001169721,0.0002959141],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9864727,"threshold_uncertainty_score":0.9996345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08055800070982055,"score_gpt":0.413548992828223,"score_spread":0.3329909921184024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}