{"id":"W1960117778","doi":"10.1039/c5mb00278h","title":"RNAi therapeutics for brain cancer: current advancements in RNAi delivery strategies","year":2015,"lang":"en","type":"review","venue":"Molecular BioSystems","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Irish Research Council; Fonds de Recherche du Québec - Santé; Irish Cancer Society","keywords":"RNA interference; Gene silencing; Angiogenesis; Blood–brain barrier; Biology; Metastasis; Cancer; Cancer research; Central nervous system; Brain tumor; Medicine; Neuroscience; Gene; Pathology; RNA; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004431414,0.000738024,0.001027934,0.001736219,0.0002724381,0.0007632694,0.0007302493,0.0008628746,0.002778659],"category_scores_gemma":[0.0003380937,0.000276283,0.0004689629,0.001278395,0.0003842331,0.001175449,0.0005059906,0.001553638,0.00193637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000523587,"about_ca_system_score_gemma":0.0006041814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005545024,"about_ca_topic_score_gemma":0.0007542148,"domain_scores_codex":[0.999845,0.00002042423,0.00001998159,0.00003019611,0.00006799757,0.00001631606],"domain_scores_gemma":[0.9998522,0.00007186323,0.00002126336,0.000005536257,0.00003602101,0.00001318704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000614902,0.0001115247,0.0001264442,0.01796236,0.00006439228,0.0003420718,0.0001122857,0.0005238659,0.02742913,0.007296261,0.01519157,0.9307787],"study_design_scores_gemma":[0.00001362558,0.0001713905,0.0004138713,0.001450025,0.00009485443,0.001523102,0.00004409046,0.0002116728,0.00792893,0.002259239,0.9858637,0.00002545742],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004045487,0.9962786,0.001033479,0.0002224464,0.0001269666,0.00001175779,0.00002161737,0.000025807,0.001874868],"genre_scores_gemma":[0.001495958,0.9964104,0.0008897044,0.0001265663,0.00007811483,0.00001652114,0.00003362085,0.000004451789,0.0009446242],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002778659,"threshold_uncertainty_score":0.009295523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08055800070982055,"score_gpt":0.413548992828223,"score_spread":0.3329909921184024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}