{"id":"W1960194941","doi":"10.4049/jimmunol.170.6.3323","title":"Redundancy of a Functional Melanocortin 1 Receptor in the Anti-inflammatory Actions of Melanocortin Peptides: Studies in the Recessive Yellow (e/e) Mouse Suggest an Important Role for Melanocortin 3 Receptor","year":2003,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Vetenskapsrådet; Wellcome Trust; Université de Sherbrooke","keywords":"Melanocortin; Melanocortins; Melanocortin 3 receptor; Melanocortin receptor; Agonist; Melanocortin 4 receptor; Internal medicine; Endocrinology; Receptor; Melanocortin 1 receptor; Melanocyte-stimulating hormone; Biology; In vivo; Antagonist; Hormone; Phenotype; Biochemistry; Medicine; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002945058,0.0001932193,0.0004087724,0.0001488231,0.0001238288,0.000008383472,0.0005044788,0.0001653679,0.00004189846],"category_scores_gemma":[0.0008466512,0.000108312,0.0001663696,0.0002254345,0.0003511311,0.00002467492,0.00003635166,0.0003294807,0.000001488478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004128668,"about_ca_system_score_gemma":0.0002167617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003196374,"about_ca_topic_score_gemma":0.0002227222,"domain_scores_codex":[0.996843,0.001183884,0.001299244,0.0001742483,0.0002385235,0.0002611228],"domain_scores_gemma":[0.9972826,0.0003488733,0.00159806,0.0004106413,0.0003351004,0.00002474531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001008304,0.000291953,0.009673455,0.00002981962,0.0002651909,0.000002962024,0.004736945,0.0001537436,0.981612,0.0005085557,0.001310689,0.0004063428],"study_design_scores_gemma":[0.003133871,0.002913859,0.02717153,0.0001370632,0.0001678856,0.0003853512,0.07898479,0.00001522172,0.8782056,0.0009479123,0.007668533,0.0002683812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948351,0.003598788,0.0001125095,0.0003412867,0.0003769441,0.0005390208,0.00002591095,0.000002408506,0.0001680701],"genre_scores_gemma":[0.9953976,0.003683559,0.0004161398,0.00009054528,0.0001404353,0.00006519704,0.00004722546,0.00001930766,0.0001399579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1034064,"threshold_uncertainty_score":0.4416837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03329943714073531,"score_gpt":0.3082033534961074,"score_spread":0.2749039163553721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}