{"id":"W1960248417","doi":"10.1002/cbic.201500402","title":"Biosynthesis of the Fluorinated Natural Product Nucleocidin in <i>Streptomyces calvus</i> Is Dependent on the <i>bldA</i>‐Specified Leu‐tRNA<sup>UUA</sup> Molecule","year":2015,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Queen's University","funders":"Erasmus+; Natural Sciences and Engineering Research Council of Canada; Deutsche Forschungsgemeinschaft; Fonds Erasme","keywords":"Chemistry; Stereochemistry; Moiety; Gene cluster; Nuclear magnetic resonance spectroscopy; Biosynthesis; Streptomyces; Complementation; Molecule; Small molecule; Natural product; Gene; Biochemistry; Organic chemistry; Biology; Genetics; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000930823,0.0004602124,0.0004410272,0.00005426287,0.0001663057,0.00003102985,0.001352461,0.0003857806,0.0006465084],"category_scores_gemma":[0.0009348009,0.0003145745,0.0002174213,0.0006900778,0.0004793137,0.00007431161,0.0004561519,0.00151096,0.0001442952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003130755,"about_ca_system_score_gemma":0.0002516823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005509161,"about_ca_topic_score_gemma":0.000007985298,"domain_scores_codex":[0.997228,0.0003064097,0.0006124718,0.0006983921,0.0005198807,0.0006348157],"domain_scores_gemma":[0.9978456,0.0004217351,0.0002897836,0.001033879,0.0002086689,0.0002003713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003729295,0.0005312296,0.003738649,0.00008744283,0.0001825632,0.00002782399,0.001492982,0.00008236127,0.9370332,0.0001558558,0.05548744,0.0008075706],"study_design_scores_gemma":[0.001428035,0.00003879795,0.0003649193,0.00005934514,0.00008813586,0.00003361117,0.0007663231,0.0003622625,0.9835822,0.0001325154,0.01280146,0.0003423939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771751,0.00142249,4.090924e-7,0.01087353,0.0006660155,0.0005455941,0.00007800107,0.00009095417,0.009147959],"genre_scores_gemma":[0.9949468,0.00008183064,0.00003855936,0.002238267,0.0003571464,0.00005789148,0.000014912,0.00006106411,0.002203481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04654904,"threshold_uncertainty_score":0.9999306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08352652291258664,"score_gpt":0.346999371966187,"score_spread":0.2634728490536004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}