{"id":"W1960248417","doi":"10.1002/cbic.201500402","title":"Biosynthesis of the Fluorinated Natural Product Nucleocidin in <i>Streptomyces calvus</i> Is Dependent on the <i>bldA</i>‐Specified Leu‐tRNA<sup>UUA</sup> Molecule","year":2015,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Queen's University","funders":"Erasmus+; Natural Sciences and Engineering Research Council of Canada; Deutsche Forschungsgemeinschaft; Fonds Erasme","keywords":"Chemistry; Stereochemistry; Moiety; Gene cluster; Nuclear magnetic resonance spectroscopy; Biosynthesis; Streptomyces; Complementation; Molecule; Small molecule; Natural product; Gene; Biochemistry; Organic chemistry; Biology; Genetics; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006219469,0.0002583205,0.0002030115,0.0001058133,0.0001576445,0.0002942428,0.0001055419,0.0002091665,0.0002533918],"category_scores_gemma":[0.000149732,0.00009103596,0.0001266591,0.0001415232,0.0001936124,0.0001568217,0.0001716666,0.0003224424,0.0001923087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003413199,"about_ca_system_score_gemma":0.0002277704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001341907,"about_ca_topic_score_gemma":0.001373307,"domain_scores_codex":[0.9999046,0.00001872251,0.000007928153,0.00002517808,0.00002844932,0.00001502933],"domain_scores_gemma":[0.9999056,0.0000204921,0.00002962244,0.00001529183,0.00000934055,0.00001966273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002742809,0.000006607404,0.0001263007,0.000007767462,9.40309e-7,0.00002970901,0.000006875043,0.00004880209,0.9989752,0.00005386954,0.000009676133,0.0007068664],"study_design_scores_gemma":[0.000004451661,0.00009946392,0.002464829,0.000002615247,0.000003788564,0.0001645815,0.00001902429,0.0004477001,0.9956881,0.00004123162,0.001060522,0.000003553424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944534,0.0005240465,0.003040299,0.00006978207,0.00001241564,0.00001242418,0.0002381814,0.00007562977,0.001573901],"genre_scores_gemma":[0.995331,0.0002609636,0.00286155,0.00002994293,0.000003814645,0.000007103584,0.0005393608,0.00002817622,0.0009380979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001341907,"threshold_uncertainty_score":0.002668142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08352652291258664,"score_gpt":0.346999371966187,"score_spread":0.2634728490536004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}