{"id":"W1960538084","doi":"10.1111/j.1468-3083.2011.04373.x","title":"Efficacy, safety and tolerability of topical terbinafine nail solution in patients with mild‐to‐moderate toenail onychomycosis: results from three randomized studies using double‐blind vehicle‐controlled and open‐label active‐controlled designs","year":2011,"lang":"en","type":"article","venue":"Journal of the European Academy of Dermatology and Venereology","topic":"Nail Diseases and Treatments","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Novartis Pharma; Novartis","keywords":"Medicine; Tolerability; Double blind; Terbinafine; Open label; Dermatology; Nail (fastener); Randomized controlled trial; Nail disease; Adverse effect; Surgery; Pharmacology; Placebo; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007738071,0.000210359,0.002147233,0.0001396409,0.0001022604,0.000006396075,0.0001708933,0.0001190472,0.000002980091],"category_scores_gemma":[0.0004310273,0.0001141881,0.000110148,0.00009008605,0.00058221,0.0001209141,0.0002304951,0.0003142035,2.204909e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003214155,"about_ca_system_score_gemma":0.00005318327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004468864,"about_ca_topic_score_gemma":0.00002256339,"domain_scores_codex":[0.9968413,0.001374563,0.001198025,0.0002545317,0.000136998,0.0001945468],"domain_scores_gemma":[0.9979771,0.0006289468,0.0009992529,0.0001330355,0.0001344679,0.0001271471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7759396,0.0007447315,0.2195057,0.00003371751,0.001539407,0.00002887236,0.0007088575,0.000009525589,0.0002605932,0.0000715762,0.000005893397,0.001151467],"study_design_scores_gemma":[0.4889932,0.0002514553,0.5085176,0.000230701,0.0009781377,0.00006691019,0.00003308236,0.0001670974,0.0003516314,0.0003472514,0.000001723666,0.00006119912],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946514,0.001889315,0.0000759144,0.001769074,0.00005937442,0.00141511,0.00001268089,0.000002932186,0.000124168],"genre_scores_gemma":[0.998374,0.0003572686,0.001044744,0.0001712348,0.00002454856,0.000005952282,0.000001713254,0.00001199711,0.000008477756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2890119,"threshold_uncertainty_score":0.4656457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1166435695795924,"score_gpt":0.3358654533715691,"score_spread":0.2192218837919767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}