{"id":"W1960885139","doi":"10.1093/carcin/bgv029","title":"Disruptive chemicals, senescence and immortality","year":2015,"lang":"en","type":"review","venue":"Carcinogenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; National Centre for the Replacement, Refinement and Reduction of Animals in Research","keywords":"Carcinogenesis; Epigenetics; Biology; Senescence; Carcinogen; Somatic evolution in cancer; Cellular adaptation; clone (Java method); Genetics; Population; Epigenesis; Mutation; Cell biology; Cancer; DNA; DNA methylation; Gene; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003347506,0.0005625315,0.001208222,0.00007115333,0.00008771513,0.00004775136,0.0003101518,0.0005431368,0.00001443975],"category_scores_gemma":[0.00005485431,0.000488987,0.000594226,0.0001793425,0.000178494,0.000003025539,0.0004949616,0.00016151,0.00001815661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008541861,"about_ca_system_score_gemma":0.0004610726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004115351,"about_ca_topic_score_gemma":0.00001718354,"domain_scores_codex":[0.9977759,0.0001590633,0.0004566458,0.0009497147,0.0002556963,0.0004029408],"domain_scores_gemma":[0.9984815,0.00001941055,0.0002250501,0.0007940512,0.0001612203,0.0003188066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002803724,0.0001158438,0.000544458,0.007399017,0.0007183507,0.00004998058,0.00005710545,5.583199e-7,0.007529382,0.00005765566,0.003675947,0.9798236],"study_design_scores_gemma":[0.0001698773,0.00009007896,0.0001290201,0.00047497,0.0008746183,0.0002016468,0.00004228843,0.000001147821,0.001843286,0.00001184724,0.9955173,0.0006439047],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003668561,0.9946982,0.00008486267,0.000009716613,0.0001636844,0.0005942821,0.0003681437,0.00001781251,0.0003946903],"genre_scores_gemma":[0.002375449,0.9956015,0.0001636259,0.00005326984,0.000468649,0.0001405823,0.00071913,0.00007770301,0.0004001092],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9918414,"threshold_uncertainty_score":0.9997562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06467921355521819,"score_gpt":0.3718280736119058,"score_spread":0.3071488600566876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}