{"id":"W1960885139","doi":"10.1093/carcin/bgv029","title":"Disruptive chemicals, senescence and immortality","year":2015,"lang":"en","type":"review","venue":"Carcinogenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; National Centre for the Replacement, Refinement and Reduction of Animals in Research","keywords":"Carcinogenesis; Epigenetics; Biology; Senescence; Carcinogen; Somatic evolution in cancer; Cellular adaptation; clone (Java method); Genetics; Population; Epigenesis; Mutation; Cell biology; Cancer; DNA; DNA methylation; Gene; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003264849,0.0008114285,0.001033006,0.002098982,0.0003200236,0.0007966198,0.0006883299,0.001034625,0.002327222],"category_scores_gemma":[0.000461192,0.0002719414,0.000446628,0.00149419,0.0006873037,0.00102106,0.000617826,0.001336092,0.001243428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007127832,"about_ca_system_score_gemma":0.0006314869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001163048,"about_ca_topic_score_gemma":0.001819707,"domain_scores_codex":[0.999827,0.00002642545,0.00002421346,0.00003621899,0.00006727105,0.00001896566],"domain_scores_gemma":[0.999786,0.00009286168,0.00004001067,0.00000977958,0.00005172248,0.00001963306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007892413,0.00009594102,0.0004126465,0.01871783,0.00009584719,0.0004022972,0.0001266643,0.0006977143,0.007676018,0.0106712,0.02217986,0.9388452],"study_design_scores_gemma":[0.000006357279,0.00006998869,0.001060253,0.001170194,0.00005829321,0.001413169,0.00004668396,0.0000841503,0.002074294,0.003357153,0.9906418,0.0000177841],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002145088,0.9981869,0.0001484522,0.0001445457,0.0001312029,0.000003565903,0.00001535341,0.000009345301,0.001146139],"genre_scores_gemma":[0.001690016,0.996991,0.0001219305,0.0001077847,0.0001124483,0.000005861954,0.00002758902,0.000001608461,0.0009418148],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002327222,"threshold_uncertainty_score":0.00778538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06467921355521819,"score_gpt":0.3718280736119058,"score_spread":0.3071488600566876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}