{"id":"W1961089940","doi":"10.1111/cmi.12266","title":"Hsp90-dependent regulatory circuitry controlling temperature-dependent fungal development and virulence","year":2014,"lang":"en","type":"review","venue":"Cellular Microbiology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Biology; Candida albicans; Virulence; Morphogenesis; Cryptococcus neoformans; Hsp90; Aspergillus fumigatus; Microbiology; Corpus albicans; Adaptation (eye); Host (biology); Fungal protein; Heat shock protein; Ecology; Genetics; Saccharomyces cerevisiae; Yeast; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.00122077,0.0008187715,0.003360835,0.0002227206,0.0002380795,0.00004533314,0.000328886,0.001385412,0.0001372381],"category_scores_gemma":[0.0001354924,0.0006415198,0.0004903211,0.0001272496,0.0003766234,0.00004153613,0.0002056901,0.001251817,0.0003071773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003915827,"about_ca_system_score_gemma":0.0009457843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000486158,"about_ca_topic_score_gemma":0.00001745994,"domain_scores_codex":[0.9959365,0.0004578754,0.001278352,0.001380523,0.0001912312,0.0007555144],"domain_scores_gemma":[0.9979053,0.0002268424,0.0004816332,0.000938325,0.0001504881,0.0002974329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002833837,0.0004450062,0.0008101997,0.06222086,0.001849686,0.00123818,0.0002610043,6.972369e-7,0.2742251,0.0004844437,0.0007804599,0.657401],"study_design_scores_gemma":[0.001061989,0.0001387256,0.0000600862,0.00656902,0.00104814,0.0009388175,0.00003811992,8.402102e-7,0.005549727,0.00001145438,0.9838306,0.0007525044],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01321128,0.9841266,0.0002484385,0.00001543359,0.0006276906,0.001280687,0.00005853172,0.00009172616,0.0003396142],"genre_scores_gemma":[0.02255762,0.9706277,0.0002670089,0.0002843307,0.0004382488,0.00007695776,0.000585763,0.0001112632,0.00505111],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9830501,"threshold_uncertainty_score":0.999911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02241558014108322,"score_gpt":0.2728255484808074,"score_spread":0.2504099683397242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}