{"id":"W1961260616","doi":"10.1371/journal.pone.0133844","title":"Genome-Wide Analyses Suggest Mechanisms Involving Early B-Cell Development in Canine IgA Deficiency","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Svenska Forskningsrådet Formas; Sveriges Lantbruksuniversitet; Vetenskapsrådet; University of Bristol; European Commission","keywords":"Genome-wide association study; Biology; Immune system; Haplotype; Genetics; Immunology; Candidate gene; Selective IgA deficiency; Gene; Antibody; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005994621,0.0002674517,0.0003013751,0.0008273007,0.0001802305,0.0005121602,0.0002758272,0.0003506677,0.001845984],"category_scores_gemma":[0.000759701,0.0001712486,0.0005123123,0.0009951143,0.000263153,0.0001782185,0.0002977625,0.000342625,0.0001539186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000126449,"about_ca_system_score_gemma":0.0001368811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001317061,"about_ca_topic_score_gemma":0.001480647,"domain_scores_codex":[0.9996456,0.00007740191,0.00002395299,0.0001572238,0.00005534008,0.00004058455],"domain_scores_gemma":[0.9995426,0.0001840438,0.0001577813,0.00003228648,0.00003011348,0.00005325679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001487373,0.00006421817,0.8714487,0.000216391,0.0009421558,0.0009319648,0.0002767564,0.0005999865,0.1073421,0.0004668997,0.0003849792,0.01583847],"study_design_scores_gemma":[0.00001664507,0.00007490709,0.9968682,0.000009205345,0.0001878242,0.0004077165,0.00005801535,0.0004155039,0.00115202,0.0001808191,0.0006250595,0.000004060247],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961665,0.001531657,0.001230486,0.00007581557,0.000007525437,0.000006492673,0.0004474985,0.00003719836,0.000496802],"genre_scores_gemma":[0.99832,0.0002777443,0.0007239182,0.00005212986,0.000005960509,0.000006039876,0.0004405682,0.00000863802,0.0001650041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001845984,"threshold_uncertainty_score":0.006175458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09475458767299211,"score_gpt":0.2852571089437809,"score_spread":0.1905025212707888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}