{"id":"W1962010571","doi":"10.1002/glia.22926","title":"Regulation of astrocyte pathology by fluoxetine prevents the deterioration of Alzheimer phenotypes in an <scp>APP/PS</scp>1 mouse model","year":2015,"lang":"en","type":"article","venue":"Glia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of Alberta; University of Manitoba","funders":"Natural Science Foundation of Anhui Province; Canadian Institutes of Health Research; Manitoba Mental Health Research Foundation; National Natural Science Foundation of China","keywords":"Astrocyte; Hippocampal formation; Neuroscience; Alzheimer's disease; Biology; Neurotoxicity; Dendritic spine; Amyloid precursor protein; Neuroglia; Phenotype; Pathology; Medicine; Disease; Central nervous system; Internal medicine; Toxicity; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001207816,0.0005952609,0.00052178,0.0005098315,0.0003096198,0.0002651903,0.0003211814,0.0005183064,0.001505681],"category_scores_gemma":[0.00009006972,0.0002171776,0.0003835317,0.0002087169,0.0003131235,0.0002448717,0.0001566964,0.0007115123,0.0004403162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003828543,"about_ca_system_score_gemma":0.0003935242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00346353,"about_ca_topic_score_gemma":0.009849018,"domain_scores_codex":[0.9998426,0.000019508,0.00002085877,0.00002778104,0.00003697079,0.00005226596],"domain_scores_gemma":[0.9998968,0.000009332971,0.00003201743,0.0000137241,0.00001463683,0.00003345486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005766417,0.0001636232,0.0001404488,0.00004613576,0.00001234686,0.00009849336,0.0000246477,0.0000411357,0.996409,0.0000798275,0.0002179639,0.002189716],"study_design_scores_gemma":[0.0001296644,0.001633405,0.005286188,0.00001568262,0.00004359704,0.0002417409,0.00005759585,0.001035315,0.9890421,0.0000929242,0.002408222,0.00001353558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991953,0.001795572,0.002065946,0.0004025883,0.0001277477,0.00008994004,0.0009542733,0.000523462,0.002087615],"genre_scores_gemma":[0.988448,0.002007709,0.002725424,0.0001699637,0.0000376457,0.000171789,0.0008901826,0.00006350625,0.005485889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00346353,"threshold_uncertainty_score":0.00688678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04461561962978591,"score_gpt":0.3183507252222254,"score_spread":0.2737351055924395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}