{"id":"W1962031907","doi":"10.1002/pro.2585","title":"Influence of hydrophobic mismatch on the catalytic activity of <scp><i>E</i></scp><i>scherichia coli</i><scp>G</scp>lp<scp>G</scp> rhomboid protease","year":2014,"lang":"en","type":"article","venue":"Protein Science","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; University of Ottawa","keywords":"Chemistry; Rhomboid; Transmembrane domain; Circular dichroism; Bilayer; Transmembrane protein; Proteases; Serine protease; Lipid bilayer; Hydrophobic effect; Protease; Alkyl; Biophysics; Protein folding; Stereochemistry; Membrane; Biochemistry; Enzyme; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001666383,0.0005331756,0.0005591428,0.0001466107,0.0004032688,0.00009559598,0.001872828,0.0003002289,0.000003325511],"category_scores_gemma":[0.00534267,0.0003949043,0.0002274293,0.001081857,0.001864665,0.00006716296,0.0005256251,0.0004877435,0.00003246947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000476549,"about_ca_system_score_gemma":0.0007067791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001960484,"about_ca_topic_score_gemma":0.00002004952,"domain_scores_codex":[0.9958942,0.0002607633,0.0005945055,0.001174475,0.001111732,0.0009643359],"domain_scores_gemma":[0.9963808,0.0003600074,0.0007242925,0.001678411,0.000498079,0.0003584049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009292459,0.0002147389,0.0009552281,0.0001599604,0.00002131776,0.000002547609,0.0004904529,0.0002128381,0.9970629,0.0001205639,0.0003317728,0.0004184145],"study_design_scores_gemma":[0.0005189913,0.0007141777,0.00710327,0.0001066128,0.00005287501,0.0000165598,0.0001710225,0.000201031,0.9829485,0.0001056086,0.007971073,0.00009024438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995073,0.0001127112,0.0001183072,0.00007784997,0.000184896,0.001992031,0.0000536669,0.00003766179,0.002349866],"genre_scores_gemma":[0.9970978,0.00002660981,0.0004411059,0.0003383232,0.0002303985,0.000316471,0.00001352568,0.00004873797,0.001486982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01411434,"threshold_uncertainty_score":0.9998503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00861431065109964,"score_gpt":0.235424873622451,"score_spread":0.2268105629713514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}