{"id":"W1962031907","doi":"10.1002/pro.2585","title":"Influence of hydrophobic mismatch on the catalytic activity of <scp><i>E</i></scp><i>scherichia coli</i><scp>G</scp>lp<scp>G</scp> rhomboid protease","year":2014,"lang":"en","type":"article","venue":"Protein Science","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; University of Ottawa","keywords":"Chemistry; Rhomboid; Transmembrane domain; Circular dichroism; Bilayer; Transmembrane protein; Proteases; Serine protease; Lipid bilayer; Hydrophobic effect; Protease; Alkyl; Biophysics; Protein folding; Stereochemistry; Membrane; Biochemistry; Enzyme; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003554095,0.000251696,0.0002092858,0.00009360565,0.0001028852,0.000422246,0.0001873446,0.0002431334,0.0007639857],"category_scores_gemma":[0.000811661,0.000155281,0.0001130219,0.0001558708,0.0002336699,0.0002741364,0.0002306208,0.0003804423,0.000182499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000279921,"about_ca_system_score_gemma":0.0002196533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001036011,"about_ca_topic_score_gemma":0.000791363,"domain_scores_codex":[0.9996601,0.0001063222,0.00004903753,0.0000506546,0.00007243753,0.00006146328],"domain_scores_gemma":[0.9994971,0.0002331767,0.0001072167,0.00003716251,0.00005038114,0.00007490935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004562755,0.00006910092,0.0008957426,0.00003351031,0.00001688757,0.00005873373,0.00004256202,0.0002782617,0.9972137,0.00005239937,0.00002100424,0.0008618669],"study_design_scores_gemma":[0.00001222752,0.0002696658,0.002621723,0.00000334653,0.00001235386,0.00004784756,0.00002942982,0.001258345,0.9954816,0.00001196817,0.0002446703,0.000006796376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994492,0.0001321244,0.0001736587,0.00001949793,0.000003038481,0.000003542324,0.00003542268,0.00000367407,0.00017976],"genre_scores_gemma":[0.9993647,0.00009595179,0.0002988928,0.00001931217,0.000002083279,0.000004642645,0.00007565803,0.000005383068,0.0001334271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001036011,"threshold_uncertainty_score":0.002555788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00861431065109964,"score_gpt":0.235424873622451,"score_spread":0.2268105629713514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}