{"id":"W196210671","doi":"10.1007/978-1-60761-863-8_15","title":"The Guideline of the Design and Validation of MiRNA Mimics","year":2010,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":160,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Canadian Institutes of Health Research","keywords":"microRNA; Gene silencing; Biology; Gene; Computational biology; Gene expression; RNA; RNA silencing; Messenger RNA; RNA interference; Endogeny; Untranslated region; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001424501,0.00008260787,0.0001224159,0.0000267701,0.00003179472,0.000003957902,0.0002848081,0.0001656099,0.000003095376],"category_scores_gemma":[0.0006642725,0.00004934757,0.00006081846,0.00007852907,0.0002824428,0.000001018668,0.0001478844,0.0001143549,2.096698e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001877382,"about_ca_system_score_gemma":0.00004266825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002312722,"about_ca_topic_score_gemma":0.00001746581,"domain_scores_codex":[0.998735,0.0006357633,0.0003065197,0.0001677028,0.00003834158,0.0001167253],"domain_scores_gemma":[0.9992588,0.00009592007,0.0001415052,0.0003839514,0.000104346,0.00001545664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003426766,0.00001196573,0.001364519,0.000003194078,0.00001898219,1.798662e-7,0.00001689937,0.00007042286,0.9880239,0.0006072908,0.00006906197,0.009779287],"study_design_scores_gemma":[0.0001493179,0.0001282517,0.0003609136,0.000003812456,0.00001000585,0.000006499365,0.00002039945,0.0002477323,0.9912928,0.003588486,0.004137496,0.00005427642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.5082442,0.0004284363,0.4907839,0.0001826173,0.0001803756,0.0001156991,0.00000218409,0.000001322891,0.00006133668],"genre_scores_gemma":[0.4105254,0.0002345235,0.5889366,0.0001952276,0.00003050936,0.00001310133,0.000006876775,0.00001216807,0.00004560894],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.09815266,"threshold_uncertainty_score":0.2012336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02093197367913341,"score_gpt":0.3739376272057808,"score_spread":0.3530056535266474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}