{"id":"W196210671","doi":"10.1007/978-1-60761-863-8_15","title":"The Guideline of the Design and Validation of MiRNA Mimics","year":2010,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":160,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Canadian Institutes of Health Research","keywords":"microRNA; Gene silencing; Biology; Gene; Computational biology; Gene expression; RNA; RNA silencing; Messenger RNA; RNA interference; Endogeny; Untranslated region; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004707028,0.001881657,0.001506697,0.001814039,0.00129046,0.001702908,0.002322371,0.002179097,0.004861706],"category_scores_gemma":[0.003280612,0.001467661,0.001411192,0.001331629,0.001137406,0.0009947404,0.0009841828,0.002128955,0.01189794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00103994,"about_ca_system_score_gemma":0.003668729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00167087,"about_ca_topic_score_gemma":0.002411123,"domain_scores_codex":[0.9955639,0.00104073,0.0006227378,0.0005441633,0.001982147,0.0002463936],"domain_scores_gemma":[0.9972108,0.0002920226,0.0002406081,0.000807319,0.001348424,0.0001008065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001574655,0.0001837745,0.0005193038,0.002042519,0.000058728,0.0004741467,0.0002075552,0.001374493,0.8730776,0.01064563,0.01315195,0.09810689],"study_design_scores_gemma":[0.00004070918,0.0003842211,0.0007734583,0.0002259412,0.00008674692,0.001028774,0.00006830828,0.001281326,0.6560761,0.001603651,0.3383739,0.00005685894],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.02439074,0.01626612,0.8746908,0.00245537,0.002353825,0.008742654,0.006447554,0.002634033,0.06201884],"genre_scores_gemma":[0.05135355,0.01881182,0.8710905,0.001458497,0.0002380739,0.007304761,0.01346502,0.0006369214,0.03564086],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.004861706,"threshold_uncertainty_score":0.0248934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02093197367913341,"score_gpt":0.3739376272057808,"score_spread":0.3530056535266474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}