{"id":"W1963042350","doi":"","title":"Phase II randomized study of ISIS 3521 and ISIS 5132 in patients with locally advanced or metastatic colorectal cancer: a National Cancer Institute of Canada clinical trials group study.","year":2002,"lang":"en","type":"article","venue":"PubMed","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Regional Cancer Foundation","funders":"","keywords":"Medicine; Colorectal cancer; Cancer; Chemotherapy; Clinical trial; Oncology; Internal medicine; Adenocarcinoma; Randomized controlled trial; Progressive disease; Phases of clinical research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002479408,0.001926715,0.002457838,0.0004047428,0.0004733654,0.0008127557,0.0009131531,0.001511147,0.006006077],"category_scores_gemma":[0.0014239,0.000634059,0.001437992,0.0006633739,0.001366456,0.0004838096,0.0003210436,0.002470946,0.0007917514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002718616,"about_ca_system_score_gemma":0.007198343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01991934,"about_ca_topic_score_gemma":0.05862349,"domain_scores_codex":[0.9991709,0.0004371329,0.00003331419,0.00009714134,0.0001062325,0.0001552979],"domain_scores_gemma":[0.9987907,0.0001630133,0.0002900395,0.00006136106,0.00009029027,0.0006046479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9639289,0.01009734,0.001955032,0.0004982008,0.0008851478,0.00007808255,0.00007808366,0.0006429836,0.004651736,0.0001615837,0.001987648,0.01503521],"study_design_scores_gemma":[0.938252,0.05696215,0.002957982,0.00001771437,0.0003071147,0.00002832315,0.00001756361,0.0003090338,0.0002389295,0.00006251672,0.0008355416,0.00001106425],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9744633,0.004002959,0.0006451152,0.001213309,0.0003093195,0.01371032,0.00235024,0.00009815535,0.003207294],"genre_scores_gemma":[0.9655903,0.003994913,0.002958742,0.002775023,0.0003553648,0.0133384,0.003653514,0.00002747688,0.007306324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01991934,"threshold_uncertainty_score":0.03960681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08020581446593113,"score_gpt":0.370629230134404,"score_spread":0.2904234156684729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}