{"id":"W1963303504","doi":"10.1517/17425255.2015.1075003","title":"Pharmacogenetics of clozapine treatment response and side-effects in schizophrenia: an update","year":2015,"lang":"en","type":"review","venue":"Expert Opinion on Drug Metabolism & Toxicology","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research; National Alliance for Research on Schizophrenia and Depression","keywords":"Clozapine; Pharmacogenetics; Schizophrenia (object-oriented programming); Medicine; Adverse effect; Psychiatry; Pharmacology; Intensive care medicine; Bioinformatics; Genotype; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009288624,0.0009267482,0.004076617,0.001272297,0.00006664491,0.0000231712,0.0002781046,0.0005331632,0.00005737648],"category_scores_gemma":[0.0003065701,0.0006565648,0.0004255956,0.0005540799,0.0002698386,0.00008335242,0.0001680831,0.0005607277,0.0000723802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004946553,"about_ca_system_score_gemma":0.001943119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006532855,"about_ca_topic_score_gemma":0.00003718484,"domain_scores_codex":[0.9939356,0.00267589,0.00106319,0.001058255,0.0005583599,0.0007087206],"domain_scores_gemma":[0.9968877,0.0007468672,0.0003901717,0.0009578487,0.0001422337,0.0008751132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0249516,0.002033919,0.000004548577,0.000886284,0.0005709982,0.0003481661,0.0002913246,0.000001488544,0.00008001111,0.0005855581,0.0004189788,0.9698271],"study_design_scores_gemma":[0.01950957,0.003288374,0.0005921227,0.001884963,0.0003544719,0.0002561153,0.0000307971,0.00002486519,0.0004894483,0.0001194372,0.9730122,0.000437614],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009170054,0.9857193,0.000002805459,0.0006390784,0.001077215,0.003144817,0.0001222174,0.00005962847,0.00006491807],"genre_scores_gemma":[0.0006146862,0.9942189,0.002450178,0.0002147535,0.0007103502,0.001151481,0.0003841091,0.0001280656,0.0001274396],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9725932,"threshold_uncertainty_score":0.9995885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07381019164683754,"score_gpt":0.4236885365414994,"score_spread":0.3498783448946619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}