{"id":"W1963422225","doi":"10.1124/mol.60.6.1243","title":"Agonist-Stimulated and Tonic Internalization of Metabotropic Glutamate Receptor 1a in Human Embryonic Kidney 293 Cells: Agonist-Stimulated Endocytosis Is β-Arrestin1 Isoform-Specific","year":2001,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Robarts Clinical Trials","funders":"","keywords":"G protein-coupled receptor; Metabotropic glutamate receptor; Cell biology; Internalization; Biology; Metabotropic receptor; HEK 293 cells; Metabotropic glutamate receptor 7; Receptor; Chemistry; Agonist; Biochemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000277701,0.0004335052,0.0005504472,0.000247689,0.0001454988,0.00004909242,0.0003747224,0.0003634309,0.001565132],"category_scores_gemma":[0.00002781457,0.0004593566,0.0001946822,0.0003447741,0.0001728168,0.00001799954,0.0002360965,0.0002803206,0.0000216073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007495433,"about_ca_system_score_gemma":0.0001168741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008531495,"about_ca_topic_score_gemma":0.000007224133,"domain_scores_codex":[0.9973406,0.0003104241,0.0007148763,0.0007865187,0.000221934,0.0006256232],"domain_scores_gemma":[0.9988598,0.00002242908,0.0003288332,0.0003624005,0.0001766962,0.0002498099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004038562,0.0001895313,0.0004256707,0.00006589545,0.0002170576,0.00007402414,0.00009544003,0.002290242,0.9939283,0.0001336837,0.00143332,0.000743034],"study_design_scores_gemma":[0.002972196,0.0006507708,0.00008538608,0.00005054132,0.0001191125,0.00002741526,0.00002115396,0.003575292,0.9496588,0.0001236,0.04230094,0.0004147498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849517,0.003236394,0.009950853,0.0002311546,0.0008316253,0.0005545811,0.00005461747,0.00003927108,0.0001497974],"genre_scores_gemma":[0.995366,0.001958792,0.000776059,0.0009660642,0.0001338348,0.00005170378,0.0003139992,0.00008064347,0.0003529318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0442694,"threshold_uncertainty_score":0.9997858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01144124471499469,"score_gpt":0.2739181877877286,"score_spread":0.2624769430727339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}