{"id":"W1963422225","doi":"10.1124/mol.60.6.1243","title":"Agonist-Stimulated and Tonic Internalization of Metabotropic Glutamate Receptor 1a in Human Embryonic Kidney 293 Cells: Agonist-Stimulated Endocytosis Is β-Arrestin1 Isoform-Specific","year":2001,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Robarts Clinical Trials","funders":"","keywords":"G protein-coupled receptor; Metabotropic glutamate receptor; Cell biology; Internalization; Biology; Metabotropic receptor; HEK 293 cells; Metabotropic glutamate receptor 7; Receptor; Chemistry; Agonist; Biochemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003675121,0.0002492903,0.0004713462,0.0002192816,0.0002957512,0.0006277717,0.0003745472,0.000373217,0.001377058],"category_scores_gemma":[0.0002534945,0.0002590987,0.0006073928,0.0003155521,0.0002602442,0.0005422638,0.0002819357,0.0009816136,0.0008917816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000871122,"about_ca_system_score_gemma":0.0004805575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001856028,"about_ca_topic_score_gemma":0.003479198,"domain_scores_codex":[0.9996163,0.00005097055,0.00005291916,0.00005709748,0.000112521,0.0001101908],"domain_scores_gemma":[0.9998618,0.00003227006,0.00002240116,0.00003542571,0.00002374592,0.00002430883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002079438,0.00002437416,0.0001532369,0.00002771701,0.000008739563,0.00006525413,0.00002495367,0.00003934628,0.9983928,0.0002586175,0.00007037403,0.0007267729],"study_design_scores_gemma":[0.00003356443,0.0000955897,0.007598694,0.000006308866,0.00001794807,0.0005705149,0.00004491776,0.001207752,0.9880539,0.00008707411,0.002271146,0.00001256303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851847,0.002492842,0.005307662,0.0003878109,0.00007035989,0.00006690229,0.002026503,0.0001239749,0.004339335],"genre_scores_gemma":[0.9854054,0.001583013,0.003942288,0.0001876849,0.00001840952,0.0000862894,0.003274107,0.00007503376,0.005427741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001856028,"threshold_uncertainty_score":0.006320477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01144124471499469,"score_gpt":0.2739181877877286,"score_spread":0.2624769430727339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}