{"id":"W1963550395","doi":"10.1371/journal.pone.0071077","title":"Geometric Attributes of Retaining Glycosyltransferase Enzymes Favor an Orthogonal Mechanism","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Glycosyltransferase; Glycosidic bond; Anomer; Chemistry; Stereochemistry; Enzyme; Acceptor; Glycoside hydrolase; Molecule; Carbohydrate conformation; Biochemistry; Nuclear magnetic resonance spectroscopy; Organic chemistry; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005814747,0.000708987,0.000698238,0.0002761216,0.0004916197,0.002163726,0.000973554,0.0007721669,0.00608185],"category_scores_gemma":[0.001286417,0.0004687926,0.0008429728,0.0004122783,0.0009370266,0.002241379,0.0005874845,0.0009388868,0.001347604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007462967,"about_ca_system_score_gemma":0.0008121008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009244868,"about_ca_topic_score_gemma":0.000882442,"domain_scores_codex":[0.9996766,0.00003761586,0.00002051855,0.0001039196,0.0000859512,0.00007543233],"domain_scores_gemma":[0.9996181,0.00008271189,0.0001070494,0.00007922604,0.0000679327,0.00004509706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00106949,0.0004630668,0.04802299,0.001337588,0.0003745825,0.001279117,0.0005539756,0.2756588,0.2728175,0.3276204,0.00264536,0.0681571],"study_design_scores_gemma":[0.0005194356,0.002945985,0.046364,0.0001028459,0.0007678438,0.003445215,0.001197535,0.4653264,0.1993365,0.2434043,0.03608209,0.0005078004],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9146279,0.0008295602,0.04948464,0.0004179888,0.00007327559,0.0001085851,0.0005184007,0.0005813292,0.03335832],"genre_scores_gemma":[0.9860129,0.0007020096,0.01063631,0.0000709574,0.00001735117,0.00003975449,0.0006313752,0.0001083611,0.001780963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00608185,"threshold_uncertainty_score":0.02034581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05037905842516326,"score_gpt":0.2076046326305532,"score_spread":0.15722557420539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}