{"id":"W1963581699","doi":"10.1016/j.tox.2011.01.024","title":"Modulation of steroidogenic gene expression and hormone synthesis in H295R cells exposed to PCP and TCP","year":2011,"lang":"en","type":"article","venue":"Toxicology","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Chinese Academy of Sciences","keywords":"Steroidogenic acute regulatory protein; Endocrinology; Hormone; Pentachlorophenol; Internal medicine; Adrenocortical carcinoma; Gene expression; Cholesterol side-chain cleavage enzyme; Cytochrome P450; Chemistry; Testosterone (patch); Endocrine system; Cell culture; Endocrine disruptor; Biology; Gene; Cell biology; Metabolism; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001163796,0.00007303823,0.0001421455,0.00003541814,0.00002017817,0.000002614066,0.00006568553,0.00005440275,0.0001735649],"category_scores_gemma":[0.00004424283,0.00006040987,0.00001274059,0.00005424869,0.00007947222,0.00004979816,0.0001472842,0.00004079179,0.00001197994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001784143,"about_ca_system_score_gemma":0.000001435283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001052529,"about_ca_topic_score_gemma":0.00003277072,"domain_scores_codex":[0.9994056,0.00004736909,0.0001462915,0.0001991668,0.00005755546,0.000143974],"domain_scores_gemma":[0.9996797,0.00009435958,0.0000481137,0.0001105701,0.000002438081,0.00006475829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004649886,0.00006176622,0.01130157,0.000005461485,0.000001812357,0.000003728926,0.0004731434,0.00003609402,0.9831913,0.000003187421,0.00007016577,0.004805281],"study_design_scores_gemma":[0.0001965585,0.0001275975,0.2186439,0.000006753266,0.000003580677,0.000003103183,0.00002864735,0.0001189612,0.7807163,0.00006949779,0.00002548352,0.00005955562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992196,0.00006664488,0.00005428116,0.00003074031,0.00002008265,0.0001532318,0.000002546026,0.000007825645,0.0004450648],"genre_scores_gemma":[0.9950169,0.000047467,0.00482008,0.0000487055,0.000006655205,0.00001564369,5.398396e-7,0.000006308004,0.00003766796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2073424,"threshold_uncertainty_score":0.2463443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02003895410569164,"score_gpt":0.2755548763189052,"score_spread":0.2555159222132136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}