{"id":"W1963581699","doi":"10.1016/j.tox.2011.01.024","title":"Modulation of steroidogenic gene expression and hormone synthesis in H295R cells exposed to PCP and TCP","year":2011,"lang":"en","type":"article","venue":"Toxicology","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Chinese Academy of Sciences","keywords":"Steroidogenic acute regulatory protein; Endocrinology; Hormone; Pentachlorophenol; Internal medicine; Adrenocortical carcinoma; Gene expression; Cholesterol side-chain cleavage enzyme; Cytochrome P450; Chemistry; Testosterone (patch); Endocrine system; Cell culture; Endocrine disruptor; Biology; Gene; Cell biology; Metabolism; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001737614,0.0002867589,0.0004659989,0.0003227656,0.0004186945,0.0004038028,0.0002667666,0.0004585714,0.001761986],"category_scores_gemma":[0.0002459539,0.000240257,0.000456273,0.000563493,0.0005800118,0.000344608,0.0001872442,0.0007612308,0.0002860962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006119084,"about_ca_system_score_gemma":0.0006666651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01246866,"about_ca_topic_score_gemma":0.00884213,"domain_scores_codex":[0.9996715,0.00005114418,0.00002847829,0.00006103284,0.00008498505,0.0001029795],"domain_scores_gemma":[0.9997407,0.00009806085,0.00002722426,0.00003399915,0.00004464341,0.00005545946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005970948,0.00004650889,0.0003627991,0.00003072672,0.000007512957,0.0001336497,0.00004012568,0.00005115373,0.9980727,0.00007781266,0.00005533685,0.0005245182],"study_design_scores_gemma":[0.00001914596,0.0004381299,0.01030781,0.000003505209,0.00002067458,0.0001326395,0.0001641031,0.0006650374,0.9871006,0.00004436313,0.001096431,0.000007591547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944189,0.001103487,0.001204624,0.0002197435,0.00007395779,0.00002916687,0.001042264,0.00003193599,0.001875902],"genre_scores_gemma":[0.992406,0.0007639082,0.001102685,0.0000884722,0.00002570563,0.0000494803,0.001272123,0.00001575458,0.004276005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01246866,"threshold_uncertainty_score":0.02479219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02003895410569164,"score_gpt":0.2755548763189052,"score_spread":0.2555159222132136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}