{"id":"W1963596430","doi":"10.1080/1475636031000069282","title":"3β-Sulfamate Derivatives of C19 and C21 Steroids Bearing a t -Butylbenzyl or a Benzyl Group: Synthesis and Evaluation as Non-estrogenic and Non-androgenic Steroid Sulfatase Inhibitors","year":2003,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; Medical Research Council Canada","keywords":"Steroid; Chemistry; Pregnenolone; Dehydroepiandrosterone; Steroid sulfatase; Estrone; Stereochemistry; Pharmacology; Endocrinology; Androgen; Biochemistry; Hormone; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008543446,0.0002523767,0.0003891941,0.00008465321,0.0001073602,0.00003406132,0.0000500005,0.0002644079,0.00001791785],"category_scores_gemma":[0.0003903529,0.0001997901,0.00007793004,0.00009817487,0.0003187819,0.00003688745,0.00006645767,0.0002622871,2.443235e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002284688,"about_ca_system_score_gemma":0.0001386103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009520749,"about_ca_topic_score_gemma":0.000002417111,"domain_scores_codex":[0.9985179,0.00009957868,0.0005419493,0.0003013375,0.0003189648,0.0002202302],"domain_scores_gemma":[0.9988843,0.00008018881,0.00043815,0.0001320164,0.000170049,0.0002953162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005275098,0.00007903615,0.001903802,0.0003008775,0.0001661475,0.00004392633,0.000265656,0.000002961573,0.9946733,0.000004779909,0.00009966159,0.001932411],"study_design_scores_gemma":[0.003156804,0.0009941413,0.00138375,0.0006206605,0.0003356688,0.002791924,0.001018749,0.00006273795,0.9892374,0.0000557966,0.0001374757,0.0002049206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895535,0.009894968,0.000083705,0.00008061801,0.00005059013,0.0001980174,0.0000146586,0.00000329541,0.0001207117],"genre_scores_gemma":[0.9965624,0.002880675,0.0002696155,0.00006294869,0.0001345969,0.00001124984,0.00002271181,0.00002140887,0.00003438181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007014293,"threshold_uncertainty_score":0.8147204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008067301433130116,"score_gpt":0.2539741818927216,"score_spread":0.2459068804595915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}