{"id":"W1963600040","doi":"10.1186/1472-6807-12-14","title":"Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family","year":2012,"lang":"en","type":"article","venue":"BMC Structural Biology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Diamond Light Source; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"Active site; Enzyme; Biochemistry; Chemistry; Aminopeptidase; Amino acid; Protein structure; Hydrolase; Stereochemistry; Lysine; Binding site; Substrate (aquarium); Residue (chemistry); Biology; Leucine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001421093,0.0005204952,0.0005202928,0.0002034782,0.0003328222,0.0005713514,0.0009325303,0.000770541,0.003015685],"category_scores_gemma":[0.000262507,0.0002262335,0.0002842894,0.0003673298,0.0002965624,0.0003205399,0.0001887697,0.0008640457,0.0003790606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00121316,"about_ca_system_score_gemma":0.0006290861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003662226,"about_ca_topic_score_gemma":0.002293593,"domain_scores_codex":[0.9998881,0.00001301039,0.000004881751,0.00002653427,0.0000460032,0.00002145691],"domain_scores_gemma":[0.9998479,0.00003962944,0.00004034514,0.000009429798,0.00002513685,0.00003763845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004804053,0.0006481687,0.02025379,0.001168294,0.0003249489,0.006798898,0.0009794844,0.02339763,0.9092164,0.003850613,0.007510065,0.02104764],"study_design_scores_gemma":[0.0009545628,0.002605209,0.1059766,0.0002022277,0.0004343677,0.01254283,0.001138119,0.2361104,0.5840669,0.003080303,0.05262289,0.0002656598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986361,0.004385883,0.003442999,0.0006828968,0.00006676088,0.00003182234,0.000918069,0.0002320652,0.003878432],"genre_scores_gemma":[0.9899099,0.001603956,0.003452047,0.0001244792,0.00001907783,0.00001841481,0.002874407,0.00003782014,0.00195999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003662226,"threshold_uncertainty_score":0.0100885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03491916807540863,"score_gpt":0.2870840712014756,"score_spread":0.252164903126067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}