{"id":"W1963652705","doi":"10.1371/journal.ppat.1002192","title":"A Quorum Sensing Regulated Small Volatile Molecule Reduces Acute Virulence and Promotes Chronic Infection Phenotypes","year":2011,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; Armand Frappier Museum","funders":"National Institute of Allergy and Infectious Diseases; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Virulence; Pseudomonas aeruginosa; Quorum sensing; Biology; Phenotype; Gene silencing; Microbiology; Regulon; Virulence factor; Chronic infection; Regulator; Mutant; Pathogen; Gene; Bacteria; Immunology; Genetics; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001112381,0.0002405135,0.0002366585,0.0001294331,0.00008673985,0.000205803,0.0001299423,0.0001893738,0.0009747874],"category_scores_gemma":[0.000118374,0.00007398037,0.0001369103,0.00008563101,0.0001732503,0.0001222392,0.0001553846,0.0003504409,0.00010462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001895006,"about_ca_system_score_gemma":0.0001739825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003692185,"about_ca_topic_score_gemma":0.0007306917,"domain_scores_codex":[0.9999141,0.00001492856,0.00000596247,0.00001405981,0.00002489899,0.00002607521],"domain_scores_gemma":[0.9998703,0.00002430078,0.00003622986,0.00001148048,0.00001325049,0.00004448213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003321181,0.000008446665,0.00008624187,0.000005627469,8.713705e-7,0.000006426128,0.000001763665,0.000009199193,0.9996347,0.000009438854,0.000003822392,0.0002000996],"study_design_scores_gemma":[0.00001592743,0.0009833812,0.01178594,0.000003589843,0.000009369253,0.0001043342,0.00002061658,0.000503775,0.9860302,0.00003473728,0.0005046668,0.000003402911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983618,0.0004543775,0.0007355404,0.0000396135,0.000007940233,0.000008947511,0.00008767578,0.0000274322,0.0002767063],"genre_scores_gemma":[0.9977227,0.0003059854,0.0007979869,0.00003042348,0.000004885293,0.00001358172,0.0001483594,0.000007476613,0.0009685819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009747874,"threshold_uncertainty_score":0.00326097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02514581494368264,"score_gpt":0.2388183466401859,"score_spread":0.2136725316965032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}