{"id":"W1963652705","doi":"10.1371/journal.ppat.1002192","title":"A Quorum Sensing Regulated Small Volatile Molecule Reduces Acute Virulence and Promotes Chronic Infection Phenotypes","year":2011,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; Armand Frappier Museum","funders":"National Institute of Allergy and Infectious Diseases; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Virulence; Pseudomonas aeruginosa; Quorum sensing; Biology; Phenotype; Gene silencing; Microbiology; Regulon; Virulence factor; Chronic infection; Regulator; Mutant; Pathogen; Gene; Bacteria; Immunology; Genetics; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009892838,0.0001781136,0.0001596692,0.00005133444,0.0001603818,0.00003049524,0.0000795447,0.000114059,0.00001631667],"category_scores_gemma":[0.0001153563,0.0001645909,0.00004915732,0.0001003145,0.0001423874,0.000008252418,0.0002281534,0.00008840719,0.00001001875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002491786,"about_ca_system_score_gemma":0.00007470922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005772803,"about_ca_topic_score_gemma":0.0001307823,"domain_scores_codex":[0.9989156,0.0000833626,0.0001536896,0.0004074959,0.0001013953,0.0003384677],"domain_scores_gemma":[0.9994568,0.000007551962,0.00007290941,0.0002561523,0.0001227447,0.00008389376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000643637,0.0000485393,0.001567096,0.00003273389,0.0001980918,0.00001412454,0.0002449795,6.305125e-7,0.9948468,0.000004970628,0.00004038817,0.002937299],"study_design_scores_gemma":[0.0002399633,0.0005194974,0.01527836,0.00004708911,0.00006920135,0.00002363863,0.00001998945,0.000494374,0.9828694,0.00005882692,0.0001755839,0.0002040066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982095,0.0006914839,0.0002214583,0.00005457966,0.00005351928,0.0002756206,0.00003270465,0.00004293851,0.0004181972],"genre_scores_gemma":[0.9968901,0.0005944109,0.002084341,0.00002342925,0.0001276547,0.00001640378,0.00004724024,0.00002961244,0.0001868295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01371127,"threshold_uncertainty_score":0.6711822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02514581494368264,"score_gpt":0.2388183466401859,"score_spread":0.2136725316965032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}