{"id":"W1963705806","doi":"10.1016/j.ceb.2012.03.007","title":"Duel of the fates: the role of transcriptional circuits and noise in CD4+ cells","year":2012,"lang":"en","type":"review","venue":"Current Opinion in Cell Biology","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"University of British Columbia; Medical Research Council; Lister Institute of Preventive Medicine","keywords":"Biology; Epigenetics; Gene expression; Cell type; Cell biology; Gene; Regulation of gene expression; Immune system; Messenger RNA; Phenotype; Epigenesis; Cell; Genetics; DNA methylation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002817699,0.0002577087,0.0006051755,0.0000837585,0.00002680379,0.000004092108,0.0004175004,0.0004078879,0.00001152263],"category_scores_gemma":[0.00001337467,0.000155622,0.0002586198,0.0001543558,0.0002894518,0.000002491987,0.00008705207,0.0003184635,0.000001593364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001504375,"about_ca_system_score_gemma":0.0001351801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003099922,"about_ca_topic_score_gemma":0.0000129824,"domain_scores_codex":[0.9984004,0.000336078,0.0006292481,0.0003175282,0.00007232436,0.0002443702],"domain_scores_gemma":[0.9992501,0.00006695419,0.0002885714,0.0003226502,0.00003575281,0.00003596415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003035295,0.0006190622,0.007294509,0.01142263,0.00005980339,5.835982e-8,0.0002889706,0.00001112979,0.1513774,0.0005622761,0.00006289495,0.828271],"study_design_scores_gemma":[0.0003623629,0.00007691229,0.0003031097,0.001234138,0.00005777615,0.000002817402,0.000026335,0.00000714795,0.005413898,0.00008886393,0.9922351,0.0001915385],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00400005,0.9926698,0.00002479612,0.000008330575,0.002430424,0.0004867974,0.0001987403,0.000001701426,0.0001793765],"genre_scores_gemma":[0.06765079,0.9318057,0.000007829343,0.000005891071,0.0002136303,0.00004240431,0.0002433734,0.00001792553,0.00001250396],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9921722,"threshold_uncertainty_score":0.634608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06361950498360361,"score_gpt":0.3121039102398434,"score_spread":0.2484844052562397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}