{"id":"W1963793299","doi":"10.1002/cbic.201000693","title":"Different Active‐Site Loop Orientation in Serine Hydrolases versus Acyltransferases","year":2011,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute; McGill University","funders":"University of Minnesota","keywords":"Active site; Acyltransferases; Chemistry; Oxyanion hole; Stereochemistry; Serine; Hydrolase; Catalytic triad; Sulfonyl; Biosynthesis; Enzyme; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004260941,0.0001546862,0.0001313225,0.0000480256,0.00003129653,0.00001037306,0.0001059077,0.0001037837,0.00009937035],"category_scores_gemma":[0.00005350949,0.0001474226,0.00007166486,0.0001303565,0.0000440823,0.000009988094,0.00004446481,0.00005701361,0.00001389037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002368645,"about_ca_system_score_gemma":0.00001990257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002873811,"about_ca_topic_score_gemma":0.0001017885,"domain_scores_codex":[0.9992044,0.00002045739,0.000175844,0.0003364489,0.00008445651,0.0001784005],"domain_scores_gemma":[0.999571,0.000007672327,0.00004525009,0.0002688196,0.0000504857,0.00005673346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004840142,0.0001986313,0.004685665,0.00001756156,0.00003089965,0.000001798507,0.0001889929,0.000005077536,0.9931905,0.00002687613,0.0001112433,0.001058712],"study_design_scores_gemma":[0.001255834,0.0002099932,0.0134182,0.00001144093,0.00002134999,0.00000170367,0.0001351072,0.00002522619,0.9841812,0.000008426334,0.0005597618,0.0001717722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975649,0.0002260323,0.0002382332,0.00001300783,0.0001314679,0.000127677,0.00001625318,0.00001447829,0.001668019],"genre_scores_gemma":[0.9982473,0.0002002574,0.00006175644,0.00004674089,0.00007913638,0.00003767307,0.0009713671,0.00001929673,0.0003365235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009009348,"threshold_uncertainty_score":0.601172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02028143553743565,"score_gpt":0.2440171659981793,"score_spread":0.2237357304607437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}