{"id":"W1963793299","doi":"10.1002/cbic.201000693","title":"Different Active‐Site Loop Orientation in Serine Hydrolases versus Acyltransferases","year":2011,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute; McGill University","funders":"University of Minnesota","keywords":"Active site; Acyltransferases; Chemistry; Oxyanion hole; Stereochemistry; Serine; Hydrolase; Catalytic triad; Sulfonyl; Biosynthesis; Enzyme; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001006004,0.0002403482,0.0002774439,0.00007190016,0.0001594849,0.0003849224,0.0002578242,0.0003461459,0.00119505],"category_scores_gemma":[0.0001936802,0.0001190098,0.0002218223,0.0001244287,0.0003522448,0.0004489648,0.0001652475,0.0005083847,0.0002279844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002847348,"about_ca_system_score_gemma":0.0001917662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005453866,"about_ca_topic_score_gemma":0.0006593909,"domain_scores_codex":[0.9999332,0.00000792117,0.000004403555,0.00001831589,0.00002082385,0.00001525246],"domain_scores_gemma":[0.9999352,0.00001298263,0.00001914596,0.000007555391,0.00000665776,0.00001839382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002587168,0.00003634606,0.001145344,0.00006660227,0.00001562943,0.0002425525,0.00008153621,0.001083644,0.9897691,0.003004189,0.00008542388,0.004210941],"study_design_scores_gemma":[0.0001515913,0.0006213639,0.01480679,0.00001403048,0.00007083497,0.001172561,0.0002338429,0.00924283,0.9639852,0.00350294,0.006148743,0.00004936954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928523,0.0004676679,0.005019553,0.0001677071,0.0000241447,0.000007458899,0.00004713405,0.00007556,0.001338537],"genre_scores_gemma":[0.9970781,0.0002201876,0.001929477,0.00003808365,0.000005709316,0.000003833203,0.00008890007,0.000008530406,0.0006271904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00119505,"threshold_uncertainty_score":0.003997803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02028143553743565,"score_gpt":0.2440171659981793,"score_spread":0.2237357304607437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}