{"id":"W1963795233","doi":"10.1089/ars.2006.8.68","title":"Regulation of Globin Gene Transcription by Heme in Erythroleukemia Cells: Analysis of Putative Heme Regulatory Motifs in the p45 NF-E2 Transcription Factor","year":2006,"lang":"en","type":"article","venue":"Antioxidants and Redox Signaling","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Thalassemia Foundation of Canada","keywords":"Hemin; Heme; Globin; Transcription factor; Molecular biology; Biology; Transcription (linguistics); Promoter; Gene; Gene expression; Cell biology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001056382,0.0003186086,0.0001334701,0.0001117178,0.0001169545,0.0001963958,0.0001121546,0.0001633334,0.0006533528],"category_scores_gemma":[0.0001095248,0.0000720816,0.0001251555,0.00007245388,0.0001903064,0.0001266859,0.000121122,0.0002679732,0.0002327918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002542374,"about_ca_system_score_gemma":0.0001172908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006697062,"about_ca_topic_score_gemma":0.0008142634,"domain_scores_codex":[0.9999181,0.00001599071,0.000007196237,0.00002395508,0.00001888939,0.00001591596],"domain_scores_gemma":[0.9999117,0.00002208798,0.00002484406,0.00001120589,0.000008440386,0.00002172825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002817272,0.000004714996,0.0001232349,0.000004381058,5.224809e-7,0.00001136307,0.000004610915,0.000009637551,0.9996362,0.00001759686,0.000002325015,0.0001574389],"study_design_scores_gemma":[0.000008656972,0.00005927753,0.006139658,0.000002683132,0.000003490429,0.0001143307,0.00001861815,0.0007371297,0.9923173,0.00003732769,0.0005594091,0.000002058408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964452,0.0004495476,0.002434329,0.00003127837,0.000005387594,0.000009833058,0.0001711207,0.00003299373,0.0004203632],"genre_scores_gemma":[0.9971475,0.0001181768,0.001496456,0.00001664191,0.000002064902,0.00001698992,0.0003309512,0.00001264958,0.000858625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006697062,"threshold_uncertainty_score":0.002185702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006882038095712293,"score_gpt":0.218833860217779,"score_spread":0.2119518221220667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}