{"id":"W1963797800","doi":"10.1002/jbt.20103","title":"Quantification of the expression and inducibility of 12 rat cytochrome P450 isoforms by quantitative RT–PCR","year":2006,"lang":"en","type":"article","venue":"Journal of Biochemical and Molecular Toxicology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"CYP1A2; Gene isoform; Cytochrome P450; Real-time polymerase chain reaction; Messenger RNA; Inducer; Molecular biology; Gene expression; Biology; CYP2E1; Chemistry; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002540874,0.002486816,0.001127433,0.002060292,0.0005734009,0.0008896454,0.0008488562,0.0008715853,0.004697456],"category_scores_gemma":[0.00126712,0.001006322,0.001213597,0.002029326,0.001086962,0.00065012,0.0004317224,0.002112519,0.002281468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005274377,"about_ca_system_score_gemma":0.000640112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003657795,"about_ca_topic_score_gemma":0.0009522462,"domain_scores_codex":[0.9969417,0.0006429907,0.0003595063,0.0009637105,0.0007886769,0.0003033272],"domain_scores_gemma":[0.9979231,0.0008224762,0.000348514,0.0002706697,0.000543853,0.00009132321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008931782,0.00006663496,0.000201323,0.0001268279,0.00001528403,0.00002373076,0.00003995332,0.00009871997,0.996344,0.0001091439,0.0000559016,0.002829041],"study_design_scores_gemma":[0.00004922458,0.00074376,0.002136357,0.00003005709,0.0001086496,0.0001519394,0.00003754815,0.001752919,0.9899775,0.0002125327,0.004773249,0.00002621723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3581218,0.008343332,0.6123027,0.0003533765,0.0005596895,0.00232029,0.0088847,0.002850203,0.006263956],"genre_scores_gemma":[0.2522437,0.00768349,0.6992754,0.0003450615,0.0003664059,0.007242609,0.01626844,0.0009485515,0.01562632],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004697456,"threshold_uncertainty_score":0.01571453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04918967283824594,"score_gpt":0.378943008312801,"score_spread":0.3297533354745551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}