{"id":"W1963806491","doi":"10.1385/mn:32:1:043","title":"Enzyme Replacement Therapy of Fabry Disease","year":2005,"lang":"en","type":"review","venue":"Molecular Neurobiology","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto; University Health Network","funders":"","keywords":"Fabry disease; Enzyme replacement therapy; Medicine; Alpha-galactosidase; Placebo; Renal function; Clinical trial; Disease; Internal medicine; Enzyme; Neurology; Cardiomyopathy; Cardiology; Urology; Surgery; Pathology; Chemistry; Biochemistry; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007851319,0.001104076,0.002551062,0.001977599,0.0002689114,0.0008480493,0.001322408,0.00114957,0.002161353],"category_scores_gemma":[0.0007422886,0.0002500499,0.0005885336,0.001878748,0.0005582671,0.001003521,0.0004556702,0.00162385,0.0015315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006330765,"about_ca_system_score_gemma":0.0006264251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001021129,"about_ca_topic_score_gemma":0.001848645,"domain_scores_codex":[0.9998285,0.0000350203,0.0000320497,0.00002919935,0.0000576866,0.00001754257],"domain_scores_gemma":[0.9997544,0.0001294884,0.00003435738,0.000009707584,0.00005016084,0.00002188022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000248037,0.0001027665,0.0001418473,0.009498386,0.0001832078,0.0007541408,0.00003449375,0.0003436174,0.001753318,0.002140824,0.02999693,0.9548025],"study_design_scores_gemma":[0.0001562177,0.0001827471,0.0009032392,0.002112574,0.0002939685,0.003770669,0.00004278014,0.0001254013,0.0008249396,0.001538622,0.9900264,0.00002260859],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001509851,0.9987238,0.000184127,0.0001418474,0.0002237484,0.000003214236,0.000009467956,0.000006697262,0.0005560739],"genre_scores_gemma":[0.001087964,0.9974809,0.0003124033,0.0002229044,0.0002411445,0.000006889669,0.00003437251,0.000001897609,0.0006114166],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002551062,"threshold_uncertainty_score":0.007230461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05851854551018985,"score_gpt":0.3797329667484776,"score_spread":0.3212144212382878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}