{"id":"W1963808306","doi":"10.1016/j.jmb.2007.11.025","title":"The Crystal Structures of Ornithine Carbamoyltransferase from Mycobacterium tuberculosis and Its Ternary Complex with Carbamoyl Phosphate and l-Norvaline Reveal the Enzyme's Catalytic Mechanism","year":2007,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Aspartate carbamoyltransferase; Ternary complex; Ornithine Carbamoyltransferase; Ternary operation; Mycobacterium tuberculosis; Enzyme; Transferase; Chemistry; Norvaline; Stereochemistry; Crystallography; Biochemistry; Amino acid; Ornithine; Tuberculosis; Valine; Allosteric regulation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002574955,0.0004586138,0.0008232904,0.0002315098,0.0006712925,0.001481058,0.0008987332,0.0009419947,0.00149082],"category_scores_gemma":[0.001221614,0.0004662686,0.0002569729,0.0008346241,0.0005112898,0.0006637163,0.0003678062,0.002143926,0.0003053221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001983966,"about_ca_system_score_gemma":0.001006961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008097586,"about_ca_topic_score_gemma":0.00809298,"domain_scores_codex":[0.999827,0.00001761307,0.00001368322,0.00003784134,0.00007075689,0.00003308831],"domain_scores_gemma":[0.9996141,0.0001390091,0.00008620054,0.00002444907,0.00005690448,0.00007943787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004813642,0.001867765,0.02285929,0.001935153,0.0003894503,0.004545027,0.001856805,0.01240372,0.8775969,0.02012886,0.01244406,0.03915935],"study_design_scores_gemma":[0.001484864,0.0007628885,0.04310467,0.0001821378,0.0003918895,0.004786827,0.001722866,0.09791526,0.8006285,0.006480154,0.04228796,0.0002518913],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867861,0.006311181,0.001882677,0.001028343,0.0001599167,0.0000227215,0.000770831,0.00014967,0.002888764],"genre_scores_gemma":[0.9907585,0.002209663,0.002813943,0.000158269,0.00002771514,0.000021897,0.001922105,0.00003717449,0.002050755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008097586,"threshold_uncertainty_score":0.01610088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006102693734162956,"score_gpt":0.234286072290859,"score_spread":0.2281833785566961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}