{"id":"W1963812298","doi":"10.1016/j.nicl.2013.05.007","title":"Multilocus genetic profiling to empower drug trials and predict brain atrophy","year":2013,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, Los Angeles; Genentech; National Institutes of Health; Eisai; Bayer HealthCare; Northern California Institute for Research and Education; U.S. National Library of Medicine; Takeda Pharmaceutical Company; Novartis Pharmaceuticals Corporation; Synarc; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Cure Alzheimer's Fund; Meso Scale Diagnostics; Schering-Plough; Medpace; F. Hoffmann-La Roche; BioClinica; Pfizer; Biogen; Alzheimer's Association; Amorfix Life Sciences; Merck; National Science Foundation Graduate Research Fellowship Program; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Alzheimer's Drug Discovery Foundation; GlaxoSmithKline; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; National Institute on Aging; Abbott Laboratories; Servier; Wyeth; University of California, San Diego; U.S. Department of Veterans Affairs; Foundation for the National Institutes of Health; National Science Foundation","keywords":"Apolipoprotein E; Alzheimer's Disease Neuroimaging Initiative; Neuroimaging; Atrophy; Clinical trial; Oncology; Disease; Sample size determination; Genetic association; Medicine; Alzheimer's disease; Psychology; Genotype; Bioinformatics; Internal medicine; Neuroscience; Biology; Genetics; Gene; Single-nucleotide polymorphism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009062155,0.0002218669,0.0007383782,0.0001008176,0.00008267059,0.00007854318,0.00011541,0.00009415498,0.0003826164],"category_scores_gemma":[0.00590765,0.0001613498,0.000277736,0.0001367497,0.0001929924,0.0001001967,0.000164204,0.0003720987,0.0009604755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001730398,"about_ca_system_score_gemma":0.0001596851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004752256,"about_ca_topic_score_gemma":0.00000163065,"domain_scores_codex":[0.9968656,0.0006778673,0.0008723746,0.0006892733,0.0004378771,0.0004570034],"domain_scores_gemma":[0.996219,0.001705905,0.0001081383,0.0005456969,0.0001605857,0.001260619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002627201,0.002488587,0.8329156,0.0001430707,0.003306737,0.002095607,0.0001253146,0.000002555431,0.00370316,0.00001180107,0.05915681,0.09342357],"study_design_scores_gemma":[0.007914972,0.002228971,0.9853377,0.00007382085,0.0005569388,0.00005591755,0.00003704364,0.0007374568,0.0006511905,0.0001477555,0.002040026,0.0002181855],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894276,0.001373484,0.00005084078,0.00577584,0.0002117414,0.002535611,0.00003789664,0.00009617096,0.0004908296],"genre_scores_gemma":[0.9911339,0.000200763,0.004849628,0.002646536,0.0005637401,0.000166903,0.00002154378,0.00005040266,0.0003665905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1524221,"threshold_uncertainty_score":0.9998174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09966611523430197,"score_gpt":0.4358121439483207,"score_spread":0.3361460287140187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}