{"id":"W1963812298","doi":"10.1016/j.nicl.2013.05.007","title":"Multilocus genetic profiling to empower drug trials and predict brain atrophy","year":2013,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, Los Angeles; Genentech; National Institutes of Health; Eisai; Bayer HealthCare; Northern California Institute for Research and Education; U.S. National Library of Medicine; Takeda Pharmaceutical Company; Novartis Pharmaceuticals Corporation; Synarc; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Cure Alzheimer's Fund; Meso Scale Diagnostics; Schering-Plough; Medpace; F. Hoffmann-La Roche; BioClinica; Pfizer; Biogen; Alzheimer's Association; Amorfix Life Sciences; Merck; National Science Foundation Graduate Research Fellowship Program; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Alzheimer's Drug Discovery Foundation; GlaxoSmithKline; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; National Institute on Aging; Abbott Laboratories; Servier; Wyeth; University of California, San Diego; U.S. Department of Veterans Affairs; Foundation for the National Institutes of Health; National Science Foundation","keywords":"Apolipoprotein E; Alzheimer's Disease Neuroimaging Initiative; Neuroimaging; Atrophy; Clinical trial; Oncology; Disease; Sample size determination; Genetic association; Medicine; Alzheimer's disease; Psychology; Genotype; Bioinformatics; Internal medicine; Neuroscience; Biology; Genetics; Gene; Single-nucleotide polymorphism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01693395,0.0007341442,0.001081331,0.001812999,0.0003952374,0.00129021,0.000589113,0.0008293893,0.003741496],"category_scores_gemma":[0.03775493,0.0003077891,0.0007241702,0.001456275,0.0005039532,0.0009232655,0.001147228,0.001154781,0.0005199604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000519339,"about_ca_system_score_gemma":0.000973867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001249702,"about_ca_topic_score_gemma":0.002910303,"domain_scores_codex":[0.9876856,0.01038892,0.0004309287,0.000621175,0.0005917948,0.0002816102],"domain_scores_gemma":[0.9734632,0.01860517,0.004346536,0.001807925,0.001003333,0.0007739161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01153782,0.001215225,0.4996313,0.0009348625,0.006402153,0.0005642076,0.0004749835,0.03286378,0.0289738,0.01028878,0.008348605,0.3987646],"study_design_scores_gemma":[0.003711186,0.0109469,0.5907885,0.0003990211,0.005692072,0.001615708,0.0004247227,0.2141332,0.02935242,0.1121026,0.03042291,0.0004107971],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8182638,0.008380673,0.154103,0.005649787,0.0002930566,0.001008415,0.004416787,0.0009279997,0.006956514],"genre_scores_gemma":[0.9508469,0.00059345,0.04606682,0.0008268962,0.000132621,0.0002049743,0.0007576355,0.0000405401,0.0005301706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01693395,"threshold_uncertainty_score":0.08955634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09966611523430197,"score_gpt":0.4358121439483207,"score_spread":0.3361460287140187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}