{"id":"W1963819705","doi":"10.1097/cad.0b013e328341185b","title":"Inhibiting aberrant Stat3 function with molecular therapeutics","year":2010,"lang":"en","type":"review","venue":"Anti-Cancer Drugs","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); University of Toronto","funders":"","keywords":"STAT3; STAT protein; Cancer research; Downregulation and upregulation; Biology; Multiple myeloma; Signal transduction; Cell biology; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001490216,0.0004674408,0.001279662,0.000208809,0.0001289531,0.00006053025,0.000105314,0.0002923137,0.0003885795],"category_scores_gemma":[0.000008922905,0.0003197473,0.0004472058,0.0003601452,0.00008194563,0.00008868273,0.00003458427,0.001284279,0.00008906252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001116367,"about_ca_system_score_gemma":0.0006218258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001583632,"about_ca_topic_score_gemma":0.00002349962,"domain_scores_codex":[0.9982126,0.00004984165,0.0005190172,0.000495526,0.000363201,0.0003598018],"domain_scores_gemma":[0.9987545,0.00006339893,0.0004150703,0.0004437851,0.0002060689,0.000117148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003275907,0.0001145034,0.00001171987,0.004236996,0.0006307319,0.00003476143,0.000123372,0.000002177564,0.003668176,0.0001262406,0.0003518336,0.9906667],"study_design_scores_gemma":[0.000503581,0.0002050667,0.000004253367,0.01550168,0.00322606,0.0001074514,0.00005754159,0.00001610234,0.00216584,0.000008339046,0.9778382,0.0003658819],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001385606,0.992406,0.0005636324,0.0001557224,0.0006640035,0.0007845882,0.00007780922,0.0001249787,0.003837714],"genre_scores_gemma":[0.001856386,0.9951044,0.000215724,0.0006870124,0.0006711108,0.0001553811,0.0002369298,0.0001504781,0.000922541],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9903008,"threshold_uncertainty_score":0.9999254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04739348485247957,"score_gpt":0.3524562118507138,"score_spread":0.3050627269982342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}