{"id":"W1963830953","doi":"10.1039/c4tb00876f","title":"Chitosan-coated nano-liposomes for the oral delivery of berberine hydrochloride","year":2014,"lang":"en","type":"article","venue":"Journal of Materials Chemistry B","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Bộ Giáo dục và Ðào tạo; China Scholarship Council","keywords":"Chitosan; Bioavailability; Liposome; Drug delivery; Materials science; Biocompatibility; Biopharmaceutical; Pharmacokinetics; In vivo; Pharmacology; Nanotechnology; Chemistry; Organic chemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001837448,0.0001876904,0.0005462586,0.00002937802,0.0001594551,0.0000287201,0.0004455545,0.0002451948,0.000526337],"category_scores_gemma":[0.0003353863,0.0001297962,0.0002042915,0.00007437785,0.0001614746,0.0001076752,0.00006300157,0.0002776695,0.000008554259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002161188,"about_ca_system_score_gemma":0.00007821039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002606116,"about_ca_topic_score_gemma":0.000001602665,"domain_scores_codex":[0.9982581,0.0002575423,0.0009016033,0.0001320369,0.0001889863,0.0002616927],"domain_scores_gemma":[0.9974895,0.0008584965,0.001127886,0.0001954079,0.0002049933,0.0001236978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001415908,0.0001300458,0.0002752344,0.0003183563,0.0004088827,0.000004586515,0.0001511059,0.0004485693,0.9932272,0.00003321574,0.00295443,0.0006324828],"study_design_scores_gemma":[0.001745618,0.0001147434,0.000174192,0.00004637588,0.0003396105,0.0001252491,0.00007388598,0.000253598,0.9321794,0.000121348,0.0646993,0.000126671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995565,0.0004651138,0.0001219597,0.0005267702,0.002367886,0.0001787329,0.00015186,0.00001518768,0.0006074686],"genre_scores_gemma":[0.9975652,0.0003442277,0.0001251465,0.0002710026,0.001346463,0.00001084185,0.00001223719,0.00001884613,0.0003060854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06174487,"threshold_uncertainty_score":0.5763021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0612940306653976,"score_gpt":0.3650925014921448,"score_spread":0.3037984708267472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}