{"id":"W1963853457","doi":"10.1172/jci75247","title":"Proteasome function is required for platelet production","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Volkswagen Foundation; National Institute of General Medical Sciences; American Heart Association","keywords":"Platelet; Function (biology); Production (economics); Proteasome; Chemistry; Computational biology; Biology; Cell biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002637071,0.0000934651,0.0002125287,0.00004242523,0.00006475457,0.00002186165,0.000103352,0.000211066,0.000009719953],"category_scores_gemma":[0.003637247,0.0000787659,0.0001979171,0.00006243442,0.0000923353,0.0000191539,0.00001733353,0.000157512,0.000007137653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007531232,"about_ca_system_score_gemma":0.0001193701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":8.032872e-7,"about_ca_topic_score_gemma":0.00000111178,"domain_scores_codex":[0.9985003,0.0001928405,0.0008241002,0.0001950588,0.0001688894,0.0001187416],"domain_scores_gemma":[0.9984223,0.00005772492,0.0007967029,0.0001707464,0.0004212366,0.0001312999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001756598,0.000147885,0.008262641,0.0001225563,0.0001578068,5.292087e-7,0.00009774114,0.0001075558,0.8604576,0.0008370506,0.04279583,0.08525623],"study_design_scores_gemma":[0.00150946,0.003539747,0.0062265,0.00007774104,0.00005513233,0.00002943017,0.00001875359,0.0003770069,0.7718551,0.01827504,0.1978762,0.0001598455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806925,0.00008976419,0.01515772,0.002324669,0.001190281,0.0003602157,0.000003774765,0.000007359552,0.0001737095],"genre_scores_gemma":[0.986498,0.00005033434,0.00678426,0.001442587,0.004645253,0.00002157773,0.0000333932,0.00001723021,0.000507361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1550804,"threshold_uncertainty_score":0.4354387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07441451484805864,"score_gpt":0.3446982882155616,"score_spread":0.270283773367503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}