{"id":"W1963853457","doi":"10.1172/jci75247","title":"Proteasome function is required for platelet production","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Volkswagen Foundation; National Institute of General Medical Sciences; American Heart Association","keywords":"Platelet; Function (biology); Production (economics); Proteasome; Chemistry; Computational biology; Biology; Cell biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001399202,0.000282491,0.0002717854,0.000246397,0.0002506397,0.0006956304,0.0001208683,0.0002964459,0.001499111],"category_scores_gemma":[0.0002266331,0.0001650078,0.000272672,0.0001226127,0.0001304234,0.0001641707,0.0002110456,0.0004416436,0.001048927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003608483,"about_ca_system_score_gemma":0.000345124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004078252,"about_ca_topic_score_gemma":0.0004715275,"domain_scores_codex":[0.9997794,0.0000252202,0.00002818211,0.00005115136,0.00006318254,0.00005290488],"domain_scores_gemma":[0.9997602,0.00002062716,0.00008730246,0.00002507773,0.00004027218,0.00006646551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001350095,0.00002010648,0.0008522322,0.00007624003,0.00001423042,0.0002836735,0.00001554943,0.00005762137,0.9933918,0.0004304724,0.0003819991,0.004341085],"study_design_scores_gemma":[0.00004724262,0.000332294,0.03804968,0.00003025154,0.00004819512,0.002963767,0.00004318893,0.0009571066,0.9321795,0.0004237486,0.0249118,0.00001318815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9446253,0.03377865,0.009218872,0.001005133,0.0002480176,0.00005589683,0.001885857,0.0006004967,0.008581889],"genre_scores_gemma":[0.9894145,0.004267421,0.001646533,0.00008423887,0.00006052293,0.00002647597,0.001133383,0.000034122,0.003332817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001499111,"threshold_uncertainty_score":0.005015016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07441451484805864,"score_gpt":0.3446982882155616,"score_spread":0.270283773367503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}