{"id":"W1963865700","doi":"10.1021/jm200739e","title":"Synthesis, Biological, and Antitumor Activity of a Highly Potent 6-Substituted Pyrrolo[2,3-<i>d</i>]pyrimidine Thienoyl Antifolate Inhibitor with Proton-Coupled Folate Transporter and Folate Receptor Selectivity over the Reduced Folate Carrier That Inhibits β-Glycinamide Ribonucleotide Formyltransferase","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Chemistry; Pyrimidine; Antifolate; Ribonucleotide; Stereochemistry; Chemical synthesis; Folate receptor; Structure–activity relationship; Biological activity; In vitro; Biochemistry; Nucleotide; Cancer cell; Antimetabolite; Toxicity","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001681929,0.0005571413,0.001329003,0.0002138441,0.0002442439,0.00003947797,0.0002648748,0.0003524532,0.000154671],"category_scores_gemma":[0.0002873025,0.0003092416,0.0002623761,0.0005074424,0.0008895274,0.0004776248,0.00006537444,0.001401301,9.307518e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001110603,"about_ca_system_score_gemma":0.0003999193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001781877,"about_ca_topic_score_gemma":0.00001737836,"domain_scores_codex":[0.9967188,0.0001383778,0.0008973693,0.0005616718,0.0009996536,0.0006841797],"domain_scores_gemma":[0.9975363,0.000260218,0.000698984,0.0004189803,0.0004727397,0.0006127727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01424982,0.0005469637,0.03464646,0.0008859697,0.0007289294,0.0006453248,0.0008854835,7.553008e-7,0.9450908,0.000002808656,0.00003560158,0.002281057],"study_design_scores_gemma":[0.004845504,0.003009835,0.1192326,0.00146089,0.0007411611,0.002249862,0.0002015328,0.0001729063,0.8676354,0.00004177192,0.00008421157,0.0003242742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969197,0.001043238,0.0001029995,0.0006098778,0.0000853837,0.001029789,0.00004941466,0.0000294985,0.0001301002],"genre_scores_gemma":[0.9970241,0.002316514,0.0002557846,0.00006603322,0.0002003381,0.00003222195,0.000007094022,0.00005550719,0.00004247504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08458617,"threshold_uncertainty_score":0.999936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02854746217915321,"score_gpt":0.2512475704783736,"score_spread":0.2227001082992204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}