{"id":"W1963865700","doi":"10.1021/jm200739e","title":"Synthesis, Biological, and Antitumor Activity of a Highly Potent 6-Substituted Pyrrolo[2,3-<i>d</i>]pyrimidine Thienoyl Antifolate Inhibitor with Proton-Coupled Folate Transporter and Folate Receptor Selectivity over the Reduced Folate Carrier That Inhibits β-Glycinamide Ribonucleotide Formyltransferase","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Chemistry; Pyrimidine; Antifolate; Ribonucleotide; Stereochemistry; Chemical synthesis; Folate receptor; Structure–activity relationship; Biological activity; In vitro; Biochemistry; Nucleotide; Cancer cell; Antimetabolite; Toxicity","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001019107,0.0003774686,0.0002747238,0.0001935167,0.0001195264,0.0001606846,0.0002321594,0.0002383244,0.0006153616],"category_scores_gemma":[0.00006752041,0.0001182854,0.0002244179,0.0001588922,0.0001057167,0.0001601914,0.00009381968,0.0003213458,0.0002634975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002321351,"about_ca_system_score_gemma":0.0002615716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005613362,"about_ca_topic_score_gemma":0.001005919,"domain_scores_codex":[0.9999408,0.00001060028,0.000006068489,0.00001044241,0.00001361056,0.00001847514],"domain_scores_gemma":[0.9999487,0.000006033435,0.00001282899,0.000007030857,0.000009401259,0.00001594354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002709143,0.000135789,0.0001741251,0.00008026663,0.00001059996,0.00009592898,0.00001925071,0.0005497837,0.9912959,0.0001400286,0.0001076805,0.007119494],"study_design_scores_gemma":[0.00009847742,0.002288965,0.001570438,0.000005283707,0.00003504446,0.0003410375,0.00000735549,0.0005875143,0.9900393,0.00003283487,0.004985436,0.000008385882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823306,0.007017678,0.005124865,0.000117494,0.00005308967,0.0001248572,0.0007686828,0.0001141209,0.004348578],"genre_scores_gemma":[0.9867732,0.004387279,0.004634098,0.00006335283,0.00003360228,0.00006975667,0.001217785,0.00001883954,0.002802085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006153616,"threshold_uncertainty_score":0.002058566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02854746217915321,"score_gpt":0.2512475704783736,"score_spread":0.2227001082992204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}