{"id":"W1963873041","doi":"10.1016/j.freeradbiomed.2004.04.018","title":"Reactive oxygen species mediate Endothelin-1-induced activation of ERK1/2, PKB, and Pyk2 signaling, as well as protein synthesis, in vascular smooth muscle cells","year":2004,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Heart And Stroke Foundation Of Quebec","keywords":"Angiotensin II; Vascular smooth muscle; Protein kinase B; Phosphorylation; NADPH oxidase; Cell biology; Signal transduction; Reactive oxygen species; Tyrosine phosphorylation; Kinase; Nicotinamide adenine dinucleotide phosphate; Chemistry; Endothelin 1; NAD(P)H oxidase; Biology; Endocrinology; Biochemistry; Oxidase test; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007804563,0.000254325,0.000764003,0.0002907237,0.00006232923,0.00000302266,0.0001177293,0.0003607313,0.0002817662],"category_scores_gemma":[0.00216144,0.0001791397,0.00006508689,0.0002226997,0.0006614818,0.00006024135,0.00005452703,0.0004283855,0.00002364004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006439078,"about_ca_system_score_gemma":0.0001460276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001185454,"about_ca_topic_score_gemma":0.00002758461,"domain_scores_codex":[0.9983501,0.0001826136,0.0004496994,0.0004370211,0.0002401526,0.0003404467],"domain_scores_gemma":[0.9985388,0.0006592967,0.000170107,0.0003109977,0.00005994787,0.0002608668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004735316,0.0001903221,0.0006071439,0.0001536655,0.00009478757,0.00007080931,0.000474793,9.838593e-7,0.9913293,0.001368402,0.00005975432,0.005176529],"study_design_scores_gemma":[0.00918598,0.002303488,0.01350551,0.001100038,0.000217443,0.000025344,0.0005031718,0.00001093052,0.9505047,0.01343535,0.008981055,0.0002270567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913521,0.001677944,0.0001157086,0.003782973,0.0001048723,0.0008064524,0.00001111987,0.00003647195,0.002112405],"genre_scores_gemma":[0.9971774,0.001068929,0.0004237903,0.0006896824,0.0004038331,0.00005495455,0.00002505198,0.0000232615,0.0001330603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04082464,"threshold_uncertainty_score":0.7305105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01337067049854198,"score_gpt":0.2573421976121275,"score_spread":0.2439715271135855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}