{"id":"W1963900982","doi":"10.1074/jbc.m802053200","title":"AMP-activated Protein Kinase Phosphorylates and Desensitizes Smooth Muscle Myosin Light Chain Kinase","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Myosin light-chain kinase; AMPK; Protein kinase A; Myosin; Phosphorylation; Calmodulin; Cell biology; Myosin-light-chain phosphatase; Rho-associated protein kinase; Chemistry; MYH7; AMP-activated protein kinase; Kinase; Biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009156443,0.0003204342,0.0001456915,0.0001797834,0.0001985691,0.0002222057,0.0001059926,0.0001801413,0.002246091],"category_scores_gemma":[0.0001107238,0.000143078,0.0001728354,0.000113446,0.0001607736,0.0001623373,0.000186797,0.0003641576,0.0007565049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002372681,"about_ca_system_score_gemma":0.0001871205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000284766,"about_ca_topic_score_gemma":0.0005043083,"domain_scores_codex":[0.9999201,0.00001093811,0.000005677214,0.00001867903,0.0000188078,0.00002572448],"domain_scores_gemma":[0.999959,0.000004534797,0.00001004634,0.00000590169,0.000005046717,0.00001555563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001628876,0.00003413382,0.0001802003,0.00008058225,0.000005158536,0.00005128049,0.000006675928,0.00004361413,0.9965654,0.0001932145,0.0001229076,0.002554027],"study_design_scores_gemma":[0.00007052094,0.0003271397,0.01586577,0.0000214861,0.00002317351,0.0003410246,0.00002284977,0.001142943,0.9701691,0.0003285581,0.01168162,0.000005874792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722053,0.01321437,0.005025325,0.0005341693,0.0002919519,0.00005271938,0.0005205593,0.0001413067,0.00801437],"genre_scores_gemma":[0.9805806,0.007121472,0.002492437,0.0002131344,0.00009460848,0.00004749897,0.0007176043,0.00001877761,0.008713893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002246091,"threshold_uncertainty_score":0.007513881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01755226162212401,"score_gpt":0.230037879499023,"score_spread":0.212485617876899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}