{"id":"W1963919142","doi":"10.1186/alzrt268","title":"Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levels","year":2014,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":160,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; National Institute on Aging; National Center for Advancing Translational Sciences; Medical Research Council; University of California, Irvine; University of California, San Francisco; University of California, San Diego; University of California, Davis; University of California, Los Angeles; National Institutes of Health; Rush University; National Institute of Neurological Disorders and Stroke; University of Pittsburgh; University of Washington; Johns Hopkins University; University of Miami; York University; Northwestern University; GHR Foundation; Emory University; Newcastle University; University of Pennsylvania; Vanderbilt University; Institute on Aging, University of Pennsylvania; University of Southern California; Massachusetts General Hospital","keywords":"Haplotype; Disease; Neurology; Tau protein; Association (psychology); Genetic association; Alzheimer's disease; Medicine; Neuroscience; Gene; Genetics; Allele; Psychology; Psychiatry; Biology; Single-nucleotide polymorphism; Internal medicine; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002368377,0.0002175739,0.000199315,0.0004108344,0.0001744868,0.0002534017,0.000120198,0.0002185475,0.002127945],"category_scores_gemma":[0.0009789355,0.00009604543,0.0001582025,0.0004015247,0.0001584069,0.0001052885,0.0001674227,0.0001881708,0.0001490815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007814083,"about_ca_system_score_gemma":0.00006925339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001022644,"about_ca_topic_score_gemma":0.001155235,"domain_scores_codex":[0.9998388,0.00003339806,0.00001445289,0.00006501794,0.00002854098,0.00001982712],"domain_scores_gemma":[0.9993486,0.0001866687,0.0002995969,0.00004052361,0.0000556874,0.0000690019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006452199,0.00002773204,0.9848372,0.00002507107,0.0001967957,0.0002063873,0.0000887224,0.000118589,0.01083037,0.00002878157,0.000120348,0.002874681],"study_design_scores_gemma":[0.00001059663,0.00007499017,0.9984071,0.000003567558,0.00005104521,0.0004270598,0.00002308353,0.0002048883,0.0006371777,0.00004846922,0.0001099466,0.000002119535],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992446,0.0001261674,0.0001636338,0.00001340435,0.000001827152,0.000002342558,0.0002507679,0.000004029513,0.0001933887],"genre_scores_gemma":[0.9995056,0.00003245198,0.0001525632,0.000006085863,0.000004636327,0.000004283389,0.0001841074,0.000002105203,0.0001080984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002127945,"threshold_uncertainty_score":0.007118702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0798657361551511,"score_gpt":0.369640704365067,"score_spread":0.2897749682099159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}