{"id":"W1963919142","doi":"10.1186/alzrt268","title":"Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levels","year":2014,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":160,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; National Institute on Aging; National Center for Advancing Translational Sciences; Medical Research Council; University of California, Irvine; University of California, San Francisco; University of California, San Diego; University of California, Davis; University of California, Los Angeles; National Institutes of Health; Rush University; National Institute of Neurological Disorders and Stroke; University of Pittsburgh; University of Washington; Johns Hopkins University; University of Miami; York University; Northwestern University; GHR Foundation; Emory University; Newcastle University; University of Pennsylvania; Vanderbilt University; Institute on Aging, University of Pennsylvania; University of Southern California; Massachusetts General Hospital","keywords":"Haplotype; Disease; Neurology; Tau protein; Association (psychology); Genetic association; Alzheimer's disease; Medicine; Neuroscience; Gene; Genetics; Allele; Psychology; Psychiatry; Biology; Single-nucleotide polymorphism; Internal medicine; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002091829,0.0003507475,0.0005464547,0.0004063082,0.0003992073,0.00008259354,0.0002517886,0.0001637487,0.0003134221],"category_scores_gemma":[0.0004198212,0.0002464161,0.0001499354,0.0005083411,0.0004148401,0.0002790702,0.0001390473,0.0005828654,0.0001021465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007267795,"about_ca_system_score_gemma":0.0004394751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003398191,"about_ca_topic_score_gemma":0.00002032042,"domain_scores_codex":[0.9945209,0.001226306,0.0003809507,0.0007382853,0.002169203,0.00096435],"domain_scores_gemma":[0.9959003,0.001099558,0.0002127595,0.0008718443,0.0007846044,0.001130978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01933103,0.003606366,0.7068338,0.0001105522,0.06122142,0.0002730555,0.001190579,0.0000169008,0.02014917,0.0004656794,0.02283565,0.1639657],"study_design_scores_gemma":[0.01700265,0.005408719,0.8067557,0.0004237173,0.003065728,0.00002139106,0.0002140717,0.0006394224,0.1420773,0.002603602,0.02103473,0.0007530291],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8601316,0.1267637,0.0002420995,0.008066188,0.00008067105,0.003190215,0.0003079509,0.0001584984,0.001059047],"genre_scores_gemma":[0.9938627,0.003837549,0.001229989,0.0002009778,0.0002359105,0.0002138261,0.0001054913,0.00009669949,0.0002167808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1632127,"threshold_uncertainty_score":0.9999988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0798657361551511,"score_gpt":0.369640704365067,"score_spread":0.2897749682099159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}