{"id":"W1963920300","doi":"10.1080/1061186042000220728","title":"Methionine Sustituted Polyamides are RNAse Mimics that Inhibit Translation","year":2004,"lang":"en","type":"article","venue":"Journal of drug targeting","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Alberta","funders":"National Cancer Institute; Canadian Institutes of Health Research; Health Canada; National Institutes of Health","keywords":"RNase P; Nucleic acid; Nuclease; RNA; Biochemistry; Translation (biology); Chemistry; Methionine; Cleave; Cleavage (geology); Protein biosynthesis; Small molecule; Ribonuclease; Benzimidazole; DNA; Combinatorial chemistry; Amino acid; Biology; Gene; Messenger RNA; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001280353,0.0003418749,0.0001730776,0.00009189666,0.0001007141,0.0002140773,0.0001370633,0.0002533068,0.0007683248],"category_scores_gemma":[0.0001895589,0.0001154974,0.0001452592,0.00009634079,0.0002055638,0.0002435735,0.0001031216,0.0003277939,0.0002664202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001618691,"about_ca_system_score_gemma":0.0001344037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000142221,"about_ca_topic_score_gemma":0.0003155211,"domain_scores_codex":[0.9999135,0.00002039619,0.000008859496,0.00001904212,0.00002441589,0.0000137984],"domain_scores_gemma":[0.999873,0.00003150828,0.00005207703,0.00001065473,0.00001297057,0.00001967962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004378695,0.000006020755,0.00005108665,0.00002965892,0.000002696158,0.00004331386,0.000008029323,0.00005440448,0.9979291,0.0002988807,0.00001604078,0.001516901],"study_design_scores_gemma":[0.000007242948,0.0002348913,0.0002549028,0.000002020461,0.000006830112,0.000166992,0.000004432853,0.0001646172,0.9966197,0.00004712297,0.002488496,0.000002729403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9716258,0.004401327,0.01836313,0.0001153317,0.00007360723,0.00006880363,0.000161641,0.0001961383,0.004994279],"genre_scores_gemma":[0.9817199,0.001577952,0.01384201,0.00004466115,0.00001793155,0.00003150689,0.0001575759,0.00002313956,0.002585261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007683248,"threshold_uncertainty_score":0.002570331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01708070443986878,"score_gpt":0.245159761166867,"score_spread":0.2280790567269982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}