{"id":"W1963931957","doi":"10.4161/epi.26112","title":"SUMOylation negatively modulates target gene occupancy of the KDM5B, a histone lysine demethylase","year":2013,"lang":"en","type":"article","venue":"Epigenetics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"H3K4me3; SUMO protein; Demethylase; Biology; Histone; Heterochromatin protein 1; Histone H3; Chromatin; Cell biology; Ubiquitin ligase; Ectopic expression; Ubiquitin; Regulation of gene expression; Gene; Gene expression; Molecular biology; Genetics; Heterochromatin; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008813854,0.0002076909,0.0001963035,0.0001392727,0.000195025,0.0002894052,0.0001597851,0.0001620109,0.001602412],"category_scores_gemma":[0.00009891201,0.0001388951,0.0001844658,0.0001473136,0.0001954981,0.0001401381,0.0002499838,0.0002393692,0.0003520143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003182361,"about_ca_system_score_gemma":0.0001443873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001047672,"about_ca_topic_score_gemma":0.001649385,"domain_scores_codex":[0.9998943,0.00001368062,0.000006729313,0.00003046691,0.00002571727,0.00002920124],"domain_scores_gemma":[0.9999441,0.000007814655,0.00001542587,0.000007283524,0.000007143384,0.00001831148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007129888,0.000007361952,0.0004064135,0.00001844077,0.000003223233,0.00001983894,0.000007051047,0.00002020231,0.9986038,0.00006271125,0.0000257404,0.0007539692],"study_design_scores_gemma":[0.000008557356,0.00006713489,0.0175283,0.000003458817,0.000009099177,0.00009209636,0.00002420348,0.0006194392,0.9796497,0.00003598304,0.001959053,0.000002945384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957371,0.001500925,0.001189291,0.00004711923,0.00002083781,0.000005573225,0.0002821094,0.00002834263,0.001188724],"genre_scores_gemma":[0.9967294,0.000399777,0.0004165746,0.00002997419,0.000003383284,0.000005255056,0.0003546118,0.00001323106,0.002047952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001602412,"threshold_uncertainty_score":0.005360603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01197882731526636,"score_gpt":0.2445459405639041,"score_spread":0.2325671132486377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}