{"id":"W1963931957","doi":"10.4161/epi.26112","title":"SUMOylation negatively modulates target gene occupancy of the KDM5B, a histone lysine demethylase","year":2013,"lang":"en","type":"article","venue":"Epigenetics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"H3K4me3; SUMO protein; Demethylase; Biology; Histone; Heterochromatin protein 1; Histone H3; Chromatin; Cell biology; Ubiquitin ligase; Ectopic expression; Ubiquitin; Regulation of gene expression; Gene; Gene expression; Molecular biology; Genetics; Heterochromatin; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001283668,0.000163326,0.0001587704,0.00003091984,0.00009166806,0.00001351707,0.0002546832,0.0001372866,0.0001394289],"category_scores_gemma":[0.0001497881,0.000127156,0.000115286,0.0001360263,0.000135791,0.000004144639,0.0001403254,0.00008352165,0.00002595057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000135812,"about_ca_system_score_gemma":0.00007395249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006591147,"about_ca_topic_score_gemma":0.00001154344,"domain_scores_codex":[0.9989609,0.0001087496,0.0002900903,0.0002510589,0.0001652008,0.0002240132],"domain_scores_gemma":[0.9990685,0.00001734315,0.0001833278,0.0004591744,0.0002009632,0.00007066963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001383111,0.00005703072,0.00973151,0.00001848574,0.00003597953,2.969798e-7,0.00009466677,0.0003619506,0.9860045,0.00004114401,0.000693453,0.002947189],"study_design_scores_gemma":[0.0002763175,0.0001319964,0.04350695,0.000009414621,0.00001804353,0.00000245593,0.00001769753,0.0005436312,0.9490118,0.001064745,0.005263821,0.0001531281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926453,0.00223108,0.003546826,0.0002337018,0.0001632222,0.000411801,0.0000487596,0.00001056051,0.0007088021],"genre_scores_gemma":[0.9883943,0.0001651818,0.009954304,0.0001594723,0.000184109,0.00004143822,0.00007061171,0.00002575403,0.001004883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03699267,"threshold_uncertainty_score":0.5185272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01197882731526636,"score_gpt":0.2445459405639041,"score_spread":0.2325671132486377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}