{"id":"W1963947961","doi":"10.1111/j.1471-4159.2007.04531.x","title":"Wild‐type superoxide dismutase acquires binding and toxic properties of ALS‐linked mutant forms through oxidation","year":2007,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":248,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"SOD1; Superoxide dismutase; Mutant; Chemistry; Molecular biology; Western blot; Wild type; Biochemistry; Transfection; Superoxide; Oxidative stress; Cell biology; Biology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001646635,0.0003528131,0.0002347756,0.0001602213,0.0001352168,0.0002436681,0.0001503026,0.0002607581,0.0007296785],"category_scores_gemma":[0.0001763458,0.0001912866,0.0002148197,0.0001012691,0.0002028854,0.0002083965,0.0001521654,0.000374078,0.0002545165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002053626,"about_ca_system_score_gemma":0.00009646048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002378964,"about_ca_topic_score_gemma":0.0002941509,"domain_scores_codex":[0.9998525,0.00002384303,0.00001748737,0.00002912318,0.00005069315,0.00002627216],"domain_scores_gemma":[0.9998842,0.00001500393,0.00003566733,0.00002189343,0.00001613095,0.00002716727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003750871,0.00001292792,0.000305107,0.00001317217,0.000004635974,0.0001172246,0.00001028693,0.00001759492,0.9990427,0.00005821114,0.00002053948,0.0003600412],"study_design_scores_gemma":[0.00001637314,0.0002812845,0.01847659,0.000006481249,0.00002054912,0.003261455,0.00003764069,0.0006311524,0.9748591,0.0001915528,0.002210837,0.000006985428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985282,0.0004145792,0.0006492637,0.00003476473,0.000009410099,0.0000043367,0.00005426967,0.00002950489,0.0002757103],"genre_scores_gemma":[0.9979033,0.000285679,0.000684998,0.00002520031,0.000005503972,0.000006187048,0.0002271103,0.00001065439,0.000851356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007296785,"threshold_uncertainty_score":0.002441049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04570957167841365,"score_gpt":0.3073019022083213,"score_spread":0.2615923305299076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}